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| Product name | CAS:1051366‑32‑5:Balixafortide |
| Description | Balixafortide is a new‑generation highly selective CXCR4 receptor antagonist cyclic peptide. Side‑chain cyclization stabilizes the pharmacophore conformation, greatly improving receptor binding affinity and metabolic stability. It competitively binds to the chemokine receptor CXCR4, blocks the SDF‑1α/CXCR4 signaling axis, inhibits tumor cell chemotactic migration and invasion, and disrupts stem cell anchoring in the bone marrow stroma, exerting tumor metastasis inhibition and hematopoietic stem cell mobilization effects. It also blocks HIV entry via the CXCR4 co‑receptor. Applied in tumor metastasis research such as multiple myeloma and breast cancer, hematopoietic stem cell transplantation mobilization, and targeted peptide drug development. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Theoretical molecular weight (Da) | ~1900 (subject to actual synthetic batch) |
| Structure type | Side‑chain cyclized modified cyclic peptide, constructed with unnatural amino acids |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Modification Type | Length (aa) |
| Balixafortide | Balixafortide; POL6326; CXCR4 antagonist | CXCR4 receptor antagonism,Tumor metastasis inhibition,Hematopoietic stem cell mobilization,Anti-HIV adjuvant,Chemokine pathway,Cyclic peptide drug | Cyclic modified peptide backbone with side-chain cyclization stabilized conformation, optimized CXCR4 binding site | Large modified cyclic peptide, subject to actual batch MS | - | ~1900 (theoretical) | Side-chain cyclization + unnatural amino acid modification | ~12 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-BAL001 | white powder | Store at -20℃, sealed, dry & protected from light, aliquoted; avoid repeated freeze-thaw cycles | Stable for 1 month at 2-8℃ sealed & dry; prepare aqueous solutions freshly before use | Stable for 7 days at 4℃; stable for 2 months at -20℃ in aliquots. **Good water solubility, freely soluble in water and physiological buffer**. Cyclic structure significantly enhances enzymatic resistance | Stable for 3 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-BAL001 | Highly selective CXCR4 antagonist that blocks chemokine signaling, inhibits tumor metastasis and mobilizes hematopoietic stem cells | Balixafortide mimics the binding conformation of endogenous chemokine SDF-1α, binds CXCR4 with high affinity and competitiveness, blocks activation of the SDF-1α/CXCR4 axis, and inhibits downstream pathways such as PI3K/Akt and MAPK, exerting multiple biological effects: blocks tumor cell chemotactic migration and invasion, inhibits metastasis and colonization; disrupts bone marrow stromal anchoring of hematopoietic stem cells to mobilize them into peripheral circulation; also blocks HIV entry via the CXCR4 co-receptor. Compared with first-generation CXCR4 antagonists, it has higher conformational stability, stronger receptor selectivity and longer in vivo half-life. | Tumor metastasis research,Hematopoietic stem cell mobilization,Chemokine pathway,HIV adjuvant therapy,Multiple myeloma research,Targeted peptide drugs | C-X-C Chemokine Receptor 4 (CXCR4); SDF-1α/CXCR4 signaling axis; Tumor metastasis and stem cell mobilization pathway |
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