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| Product name CAS:2226894‑58‑0 | PSMA‑1007 |
| Description | PSMA‑1007 is a new‑generation high‑affinity PSMA‑targeted small molecule peptide‑like ligand. It specifically binds to PSMA protein highly expressed on prostate cancer cell surfaces via the urea bond scaffold. It can be labeled with radionuclides for PET imaging of prostate cancer and metastases, and also applied in PSMA pathway research and targeted drug structure‑activity relationship analysis. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Theoretical molecular weight | ~540 Da |
| Structure type | Glu‑urea‑Lys peptide‑like small molecule with aromatic side chain modification |
Products Description
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Structure Type | Target Affinity |
| PSMA-1007 | PSMA-1007; Prostate-specific membrane antigen ligand; PSMA PET imaging precursor; CAS 2226894-58-0 | High-affinity PSMA targeting,Prostate cancer imaging,Metastasis detection,Radionuclide imaging precursor,SAR research,Urologic oncology study | Glu-urea-Lys core scaffold with aromatic hydrophobic side chain optimized binding | C₂₈H₃₃N₃O₈ (theoretical) | 539.23 | 540.58 | Peptide-like small molecule urea derivative | Nanomolar high affinity |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-P100701 | white powder | Store at -20℃, sealed, dry & protected from light, aliquoted; avoid high temperature and humidity | Solid powder stable for 2 years at 2-8℃ sealed and dry; prepare solutions freshly before labeling | Stable for 72 h at 4℃; stable for 1 month at -20℃ in aliquots. **Limited water solubility, small amount of DMSO or acetonitrile required for solubilization**. Aromatic side chains prone to oxidative degradation under light. Urea bond structure stable to acid/base | Stable for 3 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-P100701 | High-affinity PSMA targeting ligand that specifically binds prostate cancer cells for tumor imaging and targeting research | PSMA-1007 is a new-generation PSMA small molecule ligand optimized based on glutamate-urea-lysine scaffold. It mimics peptide bond structure via urea bond, and binds with high affinity and specificity to the enzymatic active site of prostate-specific membrane antigen (PSMA) highly expressed on prostate cancer cell membranes, sterically blocking its hydrolase function. Compared with first-generation PSMA ligands, aromatic side chain modifications further improve receptor affinity and in vivo tumor targeting, with lower non-target tissue background and higher imaging contrast. This molecule can be labeled with radionuclides for high-sensitivity PET imaging of primary prostate cancer, lymph node metastasis and bone metastasis, and also serves as a lead compound for structure-activity relationship screening of PSMA-targeted therapeutic drugs, receptor binding kinetics analysis and tumor targeted delivery mechanism research. | Prostate cancer research,Nuclear medicine PET imaging,Tumor metastasis study,PSMA pathway study,Targeted drug development,Urologic oncology research | Prostate-Specific Membrane Antigen (PSMA); PSMA enzymatic active site binding; Tumor targeted enrichment and imaging pathway |
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