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| Product Name | CAS:673478-49-4:Elpamotide |
| Description | Delmitide is a structurally optimized synthetic anti-inflammatory peptide. It inhibits NF-κB and MAPK pro-inflammatory pathways, reduces the release of pro-inflammatory cytokines such as TNF-α and IL-6, and alleviates inflammatory response and tissue damage. Applied in mechanism research of inflammatory bowel disease, autoimmune inflammation, acute inflammation models and anti-inflammatory drug development. |
| Peptide Purity (HPLC, %) | 95% / 98% / 99% |
| Molecular Formula | C₄₁H₅₈N₁₀O₁₂ |
| Molecular Weight (Da) | ~866.97 (subject to actual synthetic batch) |
| Terminal modifications | N-terminal acetylation, C-terminal amidation, with D-amino acids |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Full Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Average MW (Da) | N-terminal Modification | C-terminal Modification | Sequence Length (aa) |
| Delmitide | Delmitide; Anti-inflammatory octapeptide; CAS 287096-87-1 | Anti-inflammatory activity,Pro-inflammatory cytokine inhibition,NF-κB pathway inhibition,Inflammatory bowel disease study,Autoimmune inflammation,Peptide drug development | Modified octapeptide backbone with D-amino acids and hydrophobic aromatic side chains | C₄₁H₅₈N₁₀O₁₂ (theoretical) | 866.43 | 866.97 | Acetylation, no free amine | Amidation | 8 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-DEL001 | white powder | Store at -20℃, sealed, dry & protected from light, aliquoted; avoid repeated freeze-thaw cycles | Solid powder stable for 2 years at 2-8℃ sealed and dry; assist dissolution with dilute acetic acid for aqueous solutions | Stable for 72 h at 4℃; stable for 1 month at -20℃ in aliquots. **Limited water solubility, freely soluble in dilute acetic acid and aqueous organic solvents**. D-amino acids significantly enhance enzymatic resistance. Aromatic side chains prone to oxidative degradation under light | Stable for 3 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-DEL001 | D-amino acid modified anti-inflammatory octapeptide that inhibits NF-κB pathway to reduce pro-inflammatory cytokine release and alleviate tissue inflammatory damage | Delmitide is an anti-inflammatory peptide optimized by multi-site modifications. Introduction of D-amino acids and terminal blocking modifications greatly improves in vivo metabolic stability and cell permeability. After entering immune cells, it targets and regulates NF-κB and p38 MAPK signaling pathways, inhibits nuclear translocation of pro-inflammatory transcription factors, reduces the release of multiple pro-inflammatory mediators such as TNF-α, IL-1β, IL-6 and chemokines, and simultaneously reduces inflammatory cell infiltration, tissue edema and damage. This peptide exhibits significant intervention effects on various inflammation models such as intestinal inflammation, joint inflammation and acute lung injury, with no obvious immunosuppressive side effects. It serves as a core tool molecule for inflammatory disease mechanism research, anti-inflammatory peptide SAR analysis and novel immunomodulator development. | Inflammatory bowel disease study,Autoimmune inflammation research,Acute inflammation model,NF-κB pathway study,Anti-inflammatory drug development,Immunoregulatory mechanism | NF-κB signaling pathway; p38 MAPK signaling pathway; Pro-inflammatory cytokine transcriptional regulatory pathway |
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