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| Product name | CAS:68562-41-4:Mecasermin |
| Description | Mecasermin is recombinant human insulin-like growth factor-1 (rhIGF-1). It activates IGF-1 receptors to exert growth-promoting and anabolic effects, and is applied in growth replacement therapy for growth hormone insensitivity syndrome, as well as growth development and metabolic regulation mechanism research. |
| Protein purity (HPLC + SDS-PAGE, %) | ≥95%/≥98% |
| Theoretical molecular weight (Da) | 7649 (free peptide) |
| Modification type | 3 pairs of intramolecular disulfide bonds maintain conformation |
Products Description
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Full Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Terminal Modification | Sequence Length (aa) |
| Mecasermin | Mecasermin; Recombinant human IGF-1; rhIGF-1; CAS 68562-41-4 | Growth promotion,Growth hormone insensitivity syndrome,IGF-1 receptor agonist,Anabolism,Chondrogenesis,Recombinant polypeptide hormone | 70-amino acid single-chain polypeptide, 3 pairs of disulfide bonds maintain 3D active conformation | C₃₃₉H₅₄₃N₉₃O₁₀₅S₆ | 7646.17 | 7649.02 | Native free termini, no chemical modification | 70 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PRO-MEC001 | white powder | Store at -20℃, sealed, dry & protected from light, aliquoted. Strictly prohibited from repeated freeze-thaw and contact with strong reducing agents | Solid powder stable for 1 year at 2-8℃ sealed and dry; reconstituted solution stable for 7 days at 2-8℃ | Stable for 7 days at 2-8℃ under sterile conditions; stable for 3 months at -20℃ in aliquots. Good water solubility, freely soluble in acidic and physiological buffers. 3 pairs of disulfide bonds maintain conformation; strong reducing agents cause irreversible inactivation. Vigorous shaking and foaming induce protein aggregation | Stable for over 2 years at -20℃ lyophilized & protected from light |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PRO-MEC001 | Recombinant human IGF-1 polypeptide hormone that activates IGF-1 receptor to promote growth and anabolism | Mecasermin is recombinant human insulin-like growth factor-1 expressed by genetic engineering, with identical amino acid sequence to endogenous IGF-1. Three pairs of disulfide bonds maintain the native 3D conformation to ensure full receptor binding activity. It specifically binds to IGF-1 receptors on cell membrane surfaces, activates PI3K/Akt and MAPK signaling pathways, promotes proliferation and differentiation of chondrocytes and osteoblasts, and drives longitudinal bone growth. It also promotes protein synthesis, inhibits protein breakdown, and regulates glucose and lipid metabolism. Clinically used for growth replacement therapy of growth hormone insensitivity syndrome (Laron syndrome), it serves as a core tool protein in research fields such as growth development regulation, metabolic diseases, aging mechanism and cell culture. | Growth development research,Metabolic regulation study,Chondrogenesis research,Growth hormone insensitivity syndrome study,Cell culture supplement,Aging mechanism research | Insulin-like Growth Factor-1 Receptor (IGF-1R); PI3K/Akt and MAPK signaling pathways; Cell proliferation and anabolic regulation pathway |
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