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| Product Name | CAS:58-49-1: Angiotensin II 5-valine |
| Description | Angiotensin II is the core effector peptide of the renin-angiotensin-aldosterone system (RAAS). By specifically binding to AT₁ receptors in vascular smooth muscle, kidney and adrenal tissues, it mediates potent vasoconstriction, promotes aldosterone synthesis and release, enhances renal tubular sodium reabsorption and elevates blood pressure, and is also involved in pathological processes such as vascular remodeling, inflammatory response and fibrosis. The 5-valine is the native human sequence with activity fully consistent with endogenous human angiotensin II. It is a classic tool peptide for cardiovascular pharmacology, hypertension mechanism and RAAS system function research, and is also widely used in antihypertensive drug target screening and efficacy evaluation. |
| Peptide Purity (HPLC, %) | 95% / 98% / 99% |
| Molecular formula | C₅₀H₇₁N₁₃O₁₂ |
| Molecular weight (Da) | 1046.18 |
| Structure type | Linear octapeptide, native human sequence, free form / acetate |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Angiotensin II 5-valine | Angiotensin II (Val⁵) | AT₁/AT₂ receptor agonist, vasoconstrictive & hypertensive, RAAS system research tool | Natural octapeptide vasoactive peptide, human sequence with valine at position 5, linear unmodified, core effector of the renin-angiotensin system | C₅₀H₇₁N₁₃O₁₂ | 1045.54 | 1046.18 | Free form / acetate | 8 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-ANG201 | white powder | Store at -20°C, sealed, dry and protected from light. Aliquot to avoid repeated freeze-thaw cycles. | Stable for 1 month at 2–8°C in sealed dry condition; ship on ice pack recommended. | Stable for 7 days at 4°C. Freely soluble in dilute acetic acid and acidic buffers; moderate water solubility. Aqueous solution is rapidly degraded by peptidases; prepare fresh before use. | Stable for 3 years at -20°C, dry and protected from light. |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-ANG201 | Core effector peptide of the RAAS system with potent vasoconstrictive and hypertensive effects | Angiotensin II is the core effector peptide of the renin-angiotensin-aldosterone system (RAAS). By specifically binding to AT₁ receptors in vascular smooth muscle, kidney and adrenal tissues, it mediates potent vasoconstriction, promotes aldosterone synthesis and release, enhances renal tubular sodium reabsorption and elevates blood pressure, and is also involved in pathological processes such as vascular remodeling, inflammatory response and tissue fibrosis. The Val⁵ sequence is the native human variant with activity fully consistent with endogenous human angiotensin II. It is a classic tool peptide for cardiovascular pharmacology, hypertension mechanism and RAAS system function research, and is also widely used in antihypertensive drug target screening and efficacy evaluation. | Hypertension mechanism research, RAAS system function study, cardiovascular pharmacology research, antihypertensive drug screening & evaluation, vascular remodeling & fibrosis research | Angiotensin II type 1 receptor (AT₁R), type 2 receptor (AT₂R); Vasoconstriction and water-sodium metabolism regulatory pathway |
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