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| Product name | CAS:1566590-77-9;Melanotan I acetate |
| Sequence | Ac-SYS-{Nle}-EH-{d-Phe}-RWGKPV-NH2 |
| Three letter sequence | |
| Peptide purity (HPLC, %) | 95%/99% |
| Molecular formula | C78H111N21O19.xC2H4O2 |
| Molecular weight (Da) |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Amino Acid Full Name Sequence | Molecular Formula | Exact Molecular Weight (Da) | Average Molecular Weight (Da) | Terminal Modification - N-terminus | Terminal Modification - C-terminus | Sequence Length (aa) |
| Melanotan I acetate | #Melanotan I acetate; CAS 1566590-77-9; MT-I; NDP-α-MSH; Afamelanotide; [Nle4,D-Phe7]-α-MSH acetate | Melanocortin receptor agonist, Melanogenesis inducer, Photoprotection, Porphyria research, Skin pigment regulation, MC1R agonist, Sun-protective peptide, Vitiligo model research | Acetyl-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-amide | C₈₀H₁₁₅N₂₁O₂₁ | 1645.83 | 1646.93 | Acetylation (Ac-) | C-terminal amidation (-NH₂) | 13 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-MT001 | White powder | -20°C, sealed and light-proof, aliquot to avoid repeated freeze-thaw | 2~8°C, use within 1 month, prepare fresh before use | Stable for 48 h at 4°C | Stable for 3 years at -20°C |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Target / Receptor |
| PEP-MT001 | Melanotan I (Afamelanotide) is a stabilized synthetic analog of α-MSH, potent selective MC1R agonist that triggers melanin synthesis and skin photoprotection for porphyria & pigmentation disorder mechanism study | Melanotan I acetate (Afamelanotide / NDP-α-MSH) is a modified 13-amino-acid melanocyte-stimulating hormone analog. Site mutations Nle4 & D-Phe7 dramatically improve metabolic stability and receptor affinity vs native α-MSH. It selectively activates melanocortin 1 receptor (MC1R) on melanocytes to upregulate tyrosinase expression, boost melanin production and deposit, enhancing UV photoprotection of skin. It also modulates MC4R to regulate energy metabolism and anti-inflammatory pathways. Widely applied in erythropoietic protoporphyria phototoxicity protection, vitiligo, pigmentation disorder, UV skin damage models, melanocortin GPCR pharmacology, photoprotective peptide drug screening and cutaneous immune mechanism research. | Dermatopharmacology, melanocyte biology, photoprotection research, porphyria disease model, pigmentation disorder, GPCR pharmacology, sun-protective peptide drug, inflammation & immunity research | Melanocortin receptor MC1R (primary); MC3R, MC4R, MC5R |
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