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| Product name | CAS:782500-75-8:Albiglutide |
| Description | Albiglutide is an albumin-fused long-acting GLP-1 receptor agonist. Human serum albumin fusion technology greatly prolongs in vivo half-life and supports once-weekly administration. It is applied in mechanism research of type 2 diabetes and glucose metabolism disorders. |
| Protein purity (SDS-PAGE + HPLC) | 95%/98%/99% |
| Theoretical molecular weight | ~72.8 kDa |
| Expression system | Yeast recombinant expression |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Full Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Average MW (Da) | N-terminal Modification | C-terminal Modification | Sequence Length (aa) |
| Albiglutide | Albiglutide; GSK716155; Eperzan; CAS 782500-75-8 | GLP-1 receptor agonist,Long-acting glucose lowering,Albumin fusion technology,Type 2 diabetes research,Once-weekly dosing,Glucose homeostasis regulation | 2 tandem Gly2-mutated GLP-1(7-36) domains fused to the N-terminus of human serum albumin via a flexible linker (large recombinant fusion protein) | No precise small-molecule formula for large protein; subject to actual batch MS | - | ~72800 (theoretical) | Gly2 mutation in GLP-1 domain for enzyme resistance | Native HSA C-terminus | ~645 (2 GLP-1 domains + albumin backbone) |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-ALB001 | white powder | Store at -20℃, strictly protected from light, sealed and dry, stored in sterile aliquots. **Strictly prohibited from repeated freeze-thaw and vigorous shaking** | powder stable for 3 months at 2-8℃ sealed and dry; use immediately after reconstitution | Stable for 7 days at 4℃ under sterile conditions; stable for 3 months at -20℃ in aliquots. **Good water solubility, freely soluble in pure water and physiological buffer**. Protein is temperature-sensitive; repeated freeze-thaw causes aggregation and inactivation. Avoid strong acid/base and high temperature | Stable for over 2 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-ALB001 | Albumin-fused long-acting GLP-1 receptor agonist with once-weekly dosing, glucose-dependent glucose lowering, applied in type 2 diabetes mechanism research | Albiglutide is the first albumin-fused GLP-1 receptor agonist. Two Gly2-mutated GLP-1 domains are tandemly fused to the N-terminus of human serum albumin via recombinant DNA technology. Albumin fusion significantly reduces renal clearance and prolongs in vivo half-life to approximately 5 days, enabling once-weekly subcutaneous administration. It specifically activates GLP-1 receptors on islet β cells, promotes glucose-dependent insulin secretion, suppresses excessive glucagon release, delays gastric emptying and inhibits central appetite, steadily reducing fasting and postprandial blood glucose. With consistent mechanism to native GLP-1 but greatly improved metabolic stability and in vivo exposure, it serves as an important tool protein for type 2 diabetes pathogenesis research, long-acting glucose-lowering drug screening and GLP-1 pathway studies. | Type 2 diabetes research,Glucose metabolism regulation research,Long-acting protein drug development,GLP-1 pathway research,Islet function research,Endocrine metabolism research | Glucagon-Like Peptide-1 Receptor (GLP-1R); cAMP/PKA insulin secretion pathway; Gastric emptying and appetite regulation pathway |
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