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| CAS | 851199-60-5 |
| Product name | CAS:851199-60-5:Linaclotide acetate |
| Sequence | Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr (Disulfide bridges: Cys1-Cys6, Cys2-Cys10, Cys5-Cys13) |
| Three letter sequence | H-Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Molecular formula | C₅₉H₇₉N₁₅O₂₁S₆ (free peptide) |
| Molecular weight (Da) | 1507.73 (free peptide) |
| Salt form | Acetate |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Amino Acid Full Name Sequence | Molecular Formula | Exact Molecular Weight (Da) | Average Molecular Weight (Da) | N-terminal Modification | C-terminal Modification | Sequence Length (aa) |
| Linaclotide acetate | Linaclotide acetate; Linzess; Constella; CAS 851199-60-5; GC-C receptor agonist | GC-C receptor agonist,Intestinal secretion promotion,IBS-C therapy,Chronic idiopathic constipation research,Gastrointestinal regulatory peptide | Cysteine-Cysteine-Glutamic acid-Tyrosine-Cysteine-Cysteine-Asparagine-Proline-Alanine-Cysteine-Threonine-Glycine-Cysteine-Tyrosine (3 disulfide bridges for rigid conformation) | C₅₉H₇₉N₁₅O₂₁S₆ (free peptide) | 1506.43 | 1507.73 | Free amine, unmodified | Free carboxyl, unmodified | 14 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-LIN001 | white powder | Store at -20℃, strictly protected from light, sealed and dry, aliquoted; avoid repeated freeze-thaw cycles and reducing agents | Solid powder stable for 2 years sealed and dry at 2-8℃; prepare aqueous solutions freshly before use, aliquots stable for 1 month at -20℃ | Stable for 72 h at 4℃; three disulfide bridges are sensitive to reducing agents, high temperature and extreme pH, which cause conformational damage and activity loss | Stable for 3 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-LIN001 | Selective intestinal epithelial guanylate cyclase C agonist that promotes intestinal fluid secretion and motility, applied in IBS-C and chronic constipation research | Linaclotide acetate is a 14-amino acid macrocyclic peptide and selective guanylate cyclase C (GC-C) agonist. Its rigid three-dimensional structure is anchored by three disulfide bonds, enabling high-affinity binding to GC-C receptors on the apical membrane of intestinal epithelial cells. Receptor activation catalyzes intracellular cGMP production, which on one hand promotes chloride and bicarbonate secretion into the intestinal lumen via CFTR channels, increasing intestinal fluid and softening stool; on the other hand, it reduces intestinal sensory nerve sensitivity and relieves abdominal pain. This molecule does not enter the systemic circulation and acts locally in the intestine with very low systemic exposure. Clinically approved for the treatment of adult irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC), it serves as a core tool for gastrointestinal pharmacology, constipation pathogenesis research and peptide gastrointestinal drug development. | Gastrointestinal pharmacology research,Irritable bowel syndrome with constipation research,Chronic idiopathic constipation research,Intestinal secretion regulation research,Peptide gastrointestinal drug development | Guanylate Cyclase C Receptor (GC-C); cGMP/CFTR signaling pathway; Intestinal epithelial secretion regulatory pathway |
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