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| Product name | CAS:906547‑89‑5:Lonodelestat |
| Description | Lonodelestat is a highly selective, orally bioavailable small‑molecule inhibitor of human neutrophil elastase. It tightly binds to the active center of HNE, reversibly inhibits its proteolytic activity, reduces the degradation damage of elastase to lung tissue and vascular endothelium, and alleviates neutrophil‑mediated inflammatory cascade and tissue destruction. Its selectivity for HNE is significantly higher than other serine proteases, with low off‑target side effects. Applied in mechanism research of inflammatory diseases such as chronic obstructive pulmonary disease, acute lung injury, cystic fibrosis and anti‑inflammatory drug development. |
| Purity (HPLC, %) | 95%/98%/99% |
| Molecular formula | C₂₄H₃₁N₃O₅S |
| Molecular weight (Da) | 473.59 |
| Structure type | Small‑molecule organic compound, non‑peptide |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Product Attribute | Target |
| Lonodelestat | Lonodelestat; AZD9668 | Neutrophil elastase inhibition, Anti-inflammation, Lung injury protection, COPD research, Small-molecule inhibitor, Non-peptide | Heterocyclic parent nucleus with side-chain modified enzyme active binding domain | C₂₄H₃₁N₃O₅S | 473.2 | 473.59 | Non-peptide small molecule | Human Neutrophil Elastase (HNE) |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| SML-LON001 | White to off-white crystalline powder | Store at -20℃, sealed, dry & protected from light, nitrogen-protected, aliquoted; avoid repeated freeze-thaw cycles | Stable for 1 month at 2-8℃ sealed & dry; ice pack shipping recommended | Stable for 7 days at 4℃ under anhydrous conditions; prone to hydrolysis in aqueous solution, prepare freshly before use**Poor water solubility, requires organic solvents such as DMSO and DMF, easy to precipitate in physiological buffer**. Small-molecule ester bond structure prone to hydrolysis | Stable for 2 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| SML-LON001 | Highly selective small-molecule HNE inhibitor that suppresses neutrophil protease activity and alleviates inflammatory tissue damage | Lonodelestat blocks the hydrolytic destruction of extracellular matrix proteins and connective tissue by competitively binding to the serine active center of neutrophil elastase, reduces elastase-mediated lung epithelial injury, increased vascular permeability and inflammatory cell infiltration, thereby alleviating acute and chronic inflammatory tissue damage. It has high substrate-analog affinity for HNE with strong inhibitory activity, and extremely low cross-inhibitory activity on other serine proteases such as trypsin and chymotrypsin, with good target specificity. It is a classic tool compound for studying neutrophil-mediated inflammatory pathology. | Chronic obstructive pulmonary disease, Acute lung injury, Cystic fibrosis, Neutrophilic inflammation, Protease function research, Anti-inflammatory drug development | Human Neutrophil Elastase (HNE); Serine protease activity inhibitory pathway; Neutrophil-mediated inflammatory injury pathway |
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