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| Product name | CAS:1686108‑82‑6:Cotadutide |
| Description | Cotadutide is a new‑generation dual receptor agonist metabolic peptide. It can simultaneously activate GLP‑1 receptors and glucagon receptors, exerting synergistic metabolic regulatory effects: activating GLP‑1 receptors to glucose‑dependently promote insulin secretion, lower blood glucose, delay gastric emptying, and inhibit food intake; activating glucagon receptors to promote hepatic gluconeogenesis, enhance lipolysis and energy expenditure, and improve liver fat accumulation. It balances the agonistic activity of both receptors, significantly reduces weight and improves non‑alcoholic fatty liver while effectively lowering blood glucose. It is a cutting‑edge tool peptide for the research of metabolic diseases such as type 2 diabetes, obesity and NAFLD. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Theoretical molecular weight (Da) | ~4500 (subject to actual synthetic batch) |
| Structure type | Site‑modified linear long peptide, dual receptor agonistic activity |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Modification Type | Length (aa) |
| Cotadutide | Cotadutide; Dual agonist peptide | GLP-1/glucagon dual agonism, Hypoglycemic weight loss, Fatty liver improvement, Metabolic disease, Dual receptor agonist, Peptide drug | Glucagon-like peptide backbone with site modifications balancing dual receptor activity | Large modified peptide, subject to actual batch MS | - | ~4500 (theoretical) | Amino acid site substitution modification | ~40 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-COT001 | white powder | Store at -20℃, sealed, dry & protected from light, aliquoted; avoid repeated freeze-thaw cycles | Stable for 2 weeks at 2-8℃ sealed & dry; ice pack shipping recommended | Stable for 7 days at 4℃; slowly degraded by peptidases at room temperature**Moderate water solubility, soluble in dilute acetic acid or weakly acidic buffer, prone to aggregation in neutral solution**. Stability better than native glucagon-like peptide after modification | Stable for 2 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-COT001 | GLP-1R/GCGR dual receptor agonist peptide that synergistically regulates glucose and lipid metabolism, lowers blood glucose, reduces weight and improves fatty liver | Cotadutide exerts synergistic metabolic effects by simultaneously activating two G protein-coupled receptors: activates GLP-1 receptors in islets and gastrointestinal tract, promotes insulin secretion in a glucose-dependent manner, inhibits glucagon release, delays gastric emptying, reduces food intake, and steadily lowers blood glucose; activates glucagon receptors in liver and adipose tissue, promotes lipolysis, increases energy expenditure, reduces hepatic triglyceride deposition, and improves hepatic steatosis and insulin resistance. The two receptor effects are synergistic, achieving significant weight loss and liver metabolic improvement while effectively controlling blood glucose, with better effect than single GLP-1 receptor agonists. | Type 2 diabetes research, Obesity and weight loss, Non-alcoholic fatty liver, Glucose-lipid metabolism regulation, Dual receptor agonists, Metabolic peptide drugs | GLP-1 Receptor (GLP-1R) + Glucagon Receptor (GCGR); cAMP/PKA signaling pathway; Glucose-lipid metabolism and energy expenditure regulatory pathway |
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