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| Product Name | CAS:910627-26-8: CMX-2043 |
| Description | CMX-2043 is a novel mitochondria-targeted cytoprotective molecule, conjugated from active short peptide and α-tocopherol. It can target and accumulate in the mitochondrial membrane and exert tissue protective effect through multiple mechanisms: inhibits abnormal opening of mitochondrial permeability transition pore (mPTP) under ischemic stress, maintains mitochondrial membrane potential and energy metabolism homeostasis; scavenges excess reactive oxygen species and reduces oxidative stress damage; inhibits activation of mitochondrial apoptosis pathway. It shows significant tissue protection and functional improvement effects in models of myocardial infarction, cerebral ischemia and organ ischemia-reperfusion injury. It is a core tool molecule for mitochondrial pathology mechanism research and cardiovascular/cerebrovascular & organ protective drug development. |
| Peptide Purity (HPLC, %) | 95% / 98% / 99% |
| Molecular formula | C₃₈H₆₈N₂O₅S |
| Molecular weight (Da) | 664.03 |
| Structure type | Peptide-tocopherol conjugate, mitochondria-targeted modification, free form |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| CMX-2043 | CMX-2043 | Mitochondria-targeted cytoprotective peptide, antioxidant, inhibits mPTP opening, ischemia-reperfusion injury protection | Mitochondria-targeted molecule conjugated from active short peptide and α-tocopherol, accumulates in mitochondrial membrane, inhibits oxidative stress and mitochondrial apoptosis via multiple pathways, alleviates ischemia-reperfusion injury | C₃₈H₆₈N₂O₅S | 663.49 | 664.03 | Free form | Peptide-small molecule conjugate |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-CMX001 | white powder | Store at -20°C, sealed, dry and protected from light. Aliquot to avoid oxidation and repeated freeze-thaw cycles. | Stable for 1 month at 2–8°C in sealed dry condition; ship on ice pack protected from light recommended. | Stable for 14 days at 4°C. Freely soluble in DMSO and ethanol; slightly soluble in water, pre-dissolve in organic phase then dilute serially. Tocopherol moiety is sensitive to light and oxidation; protect from light during operation. | Stable for 2 years at -20°C, dry and protected from light. |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-CMX001 | Mitochondria-targeted cytoprotective peptide alleviates ischemia-reperfusion oxidative damage via multiple pathways | CMX-2043 is a novel mitochondria-targeted cytoprotective molecule conjugated from active short peptide and α-tocopherol. It can target and accumulate in the mitochondrial membrane and exert tissue protective effect through multiple mechanisms: inhibits abnormal opening of mitochondrial permeability transition pore (mPTP) under ischemic stress, maintains mitochondrial membrane potential and energy metabolism homeostasis; scavenges excess reactive oxygen species and reduces lipid peroxidation and oxidative stress damage; inhibits activation of mitochondrial apoptosis pathway and reduces cell apoptosis. It shows significant tissue protection and functional improvement effects in models of myocardial infarction, cerebral ischemia and organ ischemia-reperfusion injury. It is a core tool molecule for mitochondrial pathology mechanism research and cardiovascular/cerebrovascular & organ protective drug development. | Ischemia-reperfusion injury research, mitochondrial function & disease study, cardioprotection research, neuroprotection study, antioxidant drug development | Mitochondrial permeability transition pore (mPTP); Oxidative stress and mitochondrial apoptosis pathway |
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