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| Product name | CAS:1029890-89-8:A-30912A nucleus hydrochloride |
| Description | A-30912A nucleus is a key cyclic lipopeptide intermediate of echinocandin antifungal drugs. It specifically inhibits fungal cell wall β-1,3-glucan synthase, and serves as a synthetic precursor of anidulafungin and other agents. Applied in antifungal drug development, structure-activity relationship analysis and fungal cell wall mechanism research. |
| Purity (HPLC, %) | 90%/95%/98% |
| Theoretical molecular formula | C₄₁H₆₉N₇O₁₅·HCl |
| Theoretical molecular weight (Da) | 924.46 (hydrochloride) |
| Salt form | Hydrochloride |
Products Description
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Cyclization Mode | Sequence Length (aa) |
| A-30912A nucleus hydrochloride | A-30912A nucleus HCl; Echinocandin A nucleus; Anidulafungin precursor; CAS 1029890-89-8 | Echinocandin nucleus,Antifungal intermediate,β-1,3-glucan synthase inhibition,Cyclic lipopeptide,Antifungal drug development,Fungal cell wall research | Cyclic hexapeptide lactone backbone with multiple hydroxylated unnatural amino acids and fatty acid side chain | C₄₁H₆₉N₇O₁₅·HCl | 923.47 | 924.46 | Lactone bond cyclization | 6 (cyclohexapeptide core with unnatural amino acids) |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-A309001 | white powder | Store at -20℃, strictly sealed, dry & protected from light, aliquoted; avoid humidity and acid/base environments | Solid powder stable for 2 years at 2-8℃ sealed and dry; stock solutions prepared in DMSO or methanol | Stable for 72 h at 4℃ under anhydrous conditions. Easily hydrolyzed in aqueous phase; **aqueous solution stable for only a few hours, must be prepared freshly before use**. Lactone bond prone to ring-opening and inactivation in acid/base and aqueous phase. Extremely poor water solubility, organic solvent required | Stable for 2 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-A309001 | Echinocandin cyclic lipopeptide nucleus that inhibits fungal cell wall β-1,3-glucan synthase, key intermediate for antifungal drugs | A-30912A nucleus is a natural cyclic hexalipopeptide derived from filamentous fungal fermentation, serving as the core nucleus structure of echinocandin antifungal drugs. It specifically binds to the β-1,3-glucan synthase complex on fungal cell membranes, inhibits cell wall glucan biosynthesis, disrupts cell wall integrity and leads to fungal osmotic lysis. No homologous target in mammals with extremely low toxicity. This nucleus is a key synthetic precursor for new-generation echinocandins such as anidulafungin. Side chain modifications can optimize pharmacokinetics and antimicrobial spectrum. It serves as a core tool molecule for antifungal drug SAR research, synthetic process development and fungal cell wall biosynthesis mechanism studies. | Antifungal drug development,Fungal cell wall mechanism study,Echinocandin research,Drug synthesis process,Candida/Aspergillus research,Microbial pharmacology research | Fungal β-1,3-glucan synthase; Fungal cell wall biosynthesis pathway; Echinocandin mechanism of action |
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