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| Description | GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro, CAS: 91037-75-1) is a synthetic linear hexapeptide containing the RGD motif, sequence Gly-Arg-Gly-Asp-Ser-Pro, molecular formula C₂₂H₃₇N₉O₁₀, MW 587.58 Da. Acting as an integrin inhibitor, GRGDSP blocks integrin-mediated cell adhesion by binding integrin receptors; it is used in research on cell adhesion, migration, growth, and differentiation mechanisms. |
| Structure type | Linear 6-mer (RGD motif) |
| Solubility | Readily soluble in water, PBS |
| Storage | Powder -20°C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP), extended RGD hexapeptide, free base | GRGDSP; Gly-Arg-Gly-Asp-Ser-Pro; RGD hexapeptide; H-Gly-Arg-Gly-Asp-Ser-Pro-OH; CAS 91037-75-1 | RGD peptide, integrin ligand, cell adhesion, fibrinogen binding, free base | Linear hexapeptide H-Gly-Arg-Gly-Asp-Ser-Pro-OH; contains the canonical RGD (Arg-Gly-Asp) core, extended at the N-terminus by Gly and at the C-terminus by Ser-Pro; the C-terminal Pro helps stabilize the extended RGD conformation, improving integrin affinity and selectivity; net side-chain charge ~0 (Arg +1 / Asp -1, plus N-term +1 / C-term -1); no Cys/Met/Trp; good water solubility; CAS 91037-75-1 | C22H37N9O10 | 587.27 | 587.59 | Free base (no salt counterion); formula C22H37N9O10 (exact 587.27 / avg 587.59 Da); CAS 91037-75-1 | 6 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-GRGDSP-01 | White to off-white powder (free base; less hygroscopic than the TFA salt) | Store at -20°C, sealed, desiccated, protected from light (~2 years). Aliquot to avoid repeated freeze-thaw. No Cys/Met/Trp-low oxidation risk. As a free base it carries no TFA counterion (lowest irritation), suiting cell and in-vivo studies. | 2–8°C for up to ~1 month; working aliquots at -20°C; stable for shipping at ambient. | RGD hexapeptide with good water solubility, readily dissolved in aqueous buffers (PBS, pure water) at ≥5–10 mg/mL. No Cys (no disulfide), no Met (no oxidation), no Trp (no photo-oxidation). Prepare fresh or store working aliquots at -20°C and avoid repeated freeze-thaw; with no counterion it is well suited to salt-sensitive cell-adhesion and biomaterial-modification assays. | solid stable for ~2 years at -20°C, sealed and desiccated. The free base is less hygroscopic than the TFA salt, but keep the desiccator sealed and the weighing environment dry. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-GRGDSP-01 | The free-base extended RGD hexapeptide Gly-Arg-Gly-Asp-Ser-Pro with a C-terminal Pro that stabilizes the extended RGD conformation, enhancing integrin affinity and selectivity. It mediates cell-matrix adhesion and fibrinogen binding, and is commonly used in cell-adhesion studies and RGD functionalization of biomaterials/scaffolds. | This is the free-base extended RGD hexapeptide GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro), which flanks the canonical RGD core with Gly at the N-terminus and Ser-Pro at the C-terminus. The C-terminal Pro constrains the backbone and stabilizes the extended active conformation of the RGD tripeptide, conferring better integrin affinity and subtype selectivity than the free RGD tripeptide or GRGDS. Through its RGD core, GRGDSP engages cell-surface integrin heterodimers (αIIbβ3/GPIIb/IIIa, αvβ3, αvβ5, α5β1, etc.), mimicking the adhesion signals of ECM ligands such as fibrinogen and fibronectin, and mediating cell adhesion, spreading, migration and FAK/paxillin focal-adhesion signaling. Because its termini and side chains can be conveniently coupled to biomaterials, hydrogels or scaffolds, GRGDSP is widely used for RGD functionalization in tissue engineering and biomaterials, conferring cell attachment and growth on otherwise non-adhesive materials; it also serves as a positive control for integrin-dependent adhesion and as a competitive adhesion inhibitor. Supplied as a free base with no TFA/acetate counterion, it has the lowest cytotoxicity/irritancy and is especially suited to salt-sensitive cell culture, surface modification and in-vivo studies; containing no Cys/Met/Trp, oxidation and photo-oxidation risks are low, and it dissolves well in aqueous buffers. | Cell adhesion, integrin biology, tissue-engineering/scaffold RGD functionalization, biomaterial surface modification, angiogenesis, tumor metastasis, platelet aggregation, peptide conjugation and delivery | Integrins αIIbβ3 (GPIIb/IIIa), αvβ3, αvβ5, α5β1; fibrinogen/fibronectin binding sites; FAK/paxillin focal-adhesion signaling; biomaterial RGD conjugation |
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