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| Description | RGD peptide (GRGDNP) is a hexapeptide containing the RGD motif, sequence Gly-Arg-Gly-Asp-Asn-Pro, molecular formula C₂₃H₃₈N₁₀O₁₀, MW 614.62 Da. Via the RGD motif, the peptide binds integrin receptors and plays an important role in cell adhesion, migration, growth, and differentiation; it is used in integrin-mediated cell-behavior and surface-functionalization research. |
| Structure type | Linear 6-mer (GRGDNP, RGD-motif-containing) |
| Solubility | Readily soluble in water, PBS |
| Storage | Powder -20°C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| RGD peptide (GRGDNP), free base | GRGDNP; Gly-Arg-Gly-Asp-Asn-Pro; RGD mimetic; CAS 114681-65-1 | RGD analog, integrin ligand, cell adhesion, integrin-ECM interaction inhibitor, free base | Linear 6-aa peptide Gly-Arg-Gly-Asp-Asn-Pro (GRGDNP); retains the canonical RGD tripeptide core (Arg2-Gly3-Asp4), with position 5 being Asn instead of the Ser found in the parental fibronectin sequence GRGDSP; free N-terminal amine and free C-terminal carboxyl; net charge ~+1 (Arg +1, Asp -1); no cysteine, no disulfide bond; a minimal extended RGD cell-adhesion recognition motif | C23H38N10O10 | 614.28 | 614.62 | Free base (no counterion); formula C23H38N10O10 (exact 614.28 / avg 614.62 Da); CAS 114681-65-1 | 6 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-GRGDNP-01 | White to off-white powder (free base; less hygroscopic than the TFA salt) | Store at -20°C, sealed, desiccated, protected from light (~2 years). Aliquot to avoid repeated freeze-thaw. No Met/Trp/Cys-low oxidation and photolysis risk. The free base has no TFA counterion and is the least irritating form, suitable for salt-sensitive cell and in vivo studies. Weigh quickly and keep sealed over desiccant after opening. | 2–8°C for up to ~1 month; working aliquots at -20°C; stable for short-term shipping at ambient. | Good water solubility (≥5–10 mg/mL in water or neutral PBS); polar side chains (Asp/Asn) ensure aqueous dispersion without DMSO. Prepare working solutions fresh; stable at 4°C for 1–2 days; avoid repeated freeze-thaw. | solid stable for ~2 years at -20°C, sealed and desiccated. The free base is less hygroscopic than the TFA salt, but keep the desiccator sealed. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-GRGDNP-01 | GRGDNP is a fibronectin-derived 6-aa RGD analog (Gly-Arg-Gly-Asp-Asn-Pro) that competitively blocks RGD-recognizing integrins (notably α5β1) and inhibits cell–extracellular-matrix adhesion, widely used in cell adhesion, migration, apoptosis and angiogenesis studies. | GRGDNP is a 6-residue analog of the canonical RGD cell-adhesion motif from fibronectin, sequence Gly-Arg-Gly-Asp-Asn-Pro, in which the RGD tripeptide core is followed by an Asn-Pro dipeptide; position 5 is Asn instead of the Ser present in the natural GRGDSP sequence. GRGDNP retains recognition by RGD-dependent integrins and competitively inhibits the binding of integrins-predominantly α5β1, and also αvβ3 and αvβ5-to extracellular-matrix ligands such as fibronectin and vitronectin, thereby dose-dependently blocking cell adhesion, spreading and focal-adhesion formation on ECM-coated surfaces. In vitro it perturbs stress-fiber assembly, suppresses cell migration and proliferation, and, by disengaging integrin–ECM survival signaling (the anoikis pathway), promotes conformational activation and autoprocessing of pro-caspase-3, leading to tumor-cell apoptosis. Owing to its small size, good water solubility and lack of cytotoxic carriers, GRGDNP is routinely used as: (1) a positive-control RGD integrin ligand (against inactive mutants such as GRGESP); (2) a tool for cell-adhesion inhibition assays; (3) studies of tumor anoikis and angiogenesis; (4) competitive validation of RGD-functionalized biomaterials; and (5) integrin affinity/selectivity competition-binding experiments. The free-base form contains no TFA counterion and is suitable for salt-sensitive primary cells, co-cultures and in vivo injection. | Cell adhesion & migration, integrin biology, tumor anoikis, angiogenesis, tissue-engineering biomaterials, ECM-cell interactions, RGD integrin screening | Integrin α5β1 (primary); integrin αvβ3, αvβ5; pro-caspase-3 apoptotic pathway; RGD-binding sites of fibronectin/vitronectin |
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