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| Description | Laminin (925-933) (CAS: 110590-60-8) is the nonapeptide of laminin B1 chain residues 925-933, sequence Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg (CDPGYIGSR), molecular formula C₄₀H₆₂N₁₂O₁₄S, MW 967.06 Da. The fragment contains the YIGSR core sequence (residues 929-933) and is a classic functional peptide in studies of laminin-mediated cell adhesion, migration, and tumor-metastasis inhibition; widely used in ECM-mimetic surfaces, cell-culture substrates, and tumor biology research. |
| Structure type | Linear 9-mer (laminin B1 chain 925-933, YIGSR-containing) |
| Solubility | Readily soluble in water, PBS |
| Storage | Powder -20°C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Laminin (925-933) (Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg, laminin β1-chain 9-mer containing the YIGSR core and an N-terminal cysteine for thiol immobilization) | Laminin (925-933); C-D-P-G-Y-I-G-S-R; CDPGYIGSR; laminin B1/β1 chain residues 925-933; YIGSR precursor peptide; core active motif YIGSR (929-933); N-terminal Cys for thiol-mediated immobilization; CAS 110590-60-8; free acid | cell-adhesion peptide, extracellular matrix peptide, laminin, YIGSR, 67 kDa laminin receptor (LAMR1), cell migration, neurite outgrowth, tumor cell adhesion, thiol immobilization, free cysteine thiol, oxidation-prone, free acid | Linear 9-aa bioactive laminin peptide, sequence Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg (C-D-P-G-Y-I-G-S-R, CDPGYIGSR); derived from laminin β1 (B1) chain residues 925-933; the C-terminal pentapeptide YIGSR (Tyr-Ile-Gly-Ser-Arg, residues 929-933) is the core cell-adhesion motif, while the N-terminal CDPG extension provides a free cysteine; side-chain net charge ~0 (Asp -1, Arg +1; ~0 including N-terminus +1 and C-terminus -1); CRITICAL: the N-terminal Cys bears a free thiol (-SH) with NO intramolecular disulfide partner-it readily oxidizes to Cys-Cys disulfide dimer/oligomer; contains one Tyr (minor photosensitivity), no Met; supplied as the free acid; CAS 110590-60-8 | C40H62N12O14S | 966.42 | 967.07 | Free acid; no counterion; CAS 110590-60-8 | 9 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-LAM933-01 | White to off-white powder | CRITICAL-contains a free N-terminal Cys thiol that oxidizes readily: store the lyophilate SEALED under argon (or nitrogen/inert gas), desiccated and protected from light (recommended -20°C, ~1–2 years). Aliquot to avoid repeated freeze-thaw and repeated opening. Exclude oxygen and oxidants; avoid contact with copper, iron and other redox-active metal ions (metals catalyze thiol oxidation); weigh quickly and immediately re-seal under inert gas. | 2–8°C, desiccated, protected from light, under inert gas (~2 weeks); prepare working solutions fresh. | CRITICAL-poor free-thiol stability: in aqueous solution the Cys thiol readily oxidizes to an intermolecular disulfide dimer (CDPGYIGSR-S-S-CDPGYIGSR) and even oligomers, reducing activity. PREPARE FRESH and use promptly; exclude oxidants (atmospheric oxygen, H2O2, denaturants); degas/sparge solutions with argon/nitrogen; do NOT freeze-thaw repeatedly; keep Cu/Fe out of buffers-a trace-metal chelator such as low-dose EDTA is advisable. The YIGSR core is hydrophilic and the peptide is soluble in water/aqueous buffers. The N-terminal free Cys thiol is deliberately included for covalent immobilization-conjugate via maleimide or other thiol-reactive chemistry onto materials/hydrogels/scaffolds to display the YIGSR active moiety outward. | solid stable ~1–2 years at -20°C, sealed under argon, desiccated and protected from light. Because the free thiol oxidizes readily, keep it inert-gas-sealed and dry; weigh in a dry environment, quickly, and re-seal under inert gas immediately-do not leave it open to air. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-LAM933-01 | The laminin β1-chain 9-mer CDPGYIGSR (residues 925-933); its YIGSR core binds the 67 kDa laminin receptor (LAMR1/RPSA-p40) to mediate cell adhesion, migration, tumor-cell adhesion and neurite outgrowth, while the N-terminal free Cys thiol is used for oriented thiol immobilization onto scaffolds-strict anti-oxidation handling is required. | This is a synthetic 9-mer from laminin β1 (B1) chain residues 925-933 and one of the best-studied laminin-derived active peptides. Its C-terminal pentapeptide YIGSR (Tyr-Ile-Gly-Ser-Arg, residues 929-933) is the minimal cell-adhesion motif; by specifically engaging the cell-surface 67 kDa laminin receptor (67LR, i.e., LAMR1/RPSA, the ribosome-associated p40 protein) it mediates cell attachment, spreading and migration on basement membrane, and participates in tumor-cell adhesion/metastasis, endothelial eNOS regulation, sensory axonal responses and neurite outgrowth. Soluble YIGSR can also competitively block tumor-cell binding to laminin and thereby suppress tumor growth and experimental metastasis. The extra N-terminal CDPG segment is not required for activity-its sole purpose is to supply a free cysteine: this thiol is used to covalently and orientedly immobilize the peptide onto biomaterials, hydrogels or tissue-engineering scaffolds (via maleimide-type thiol chemistry), presenting the YIGSR active moiety outward to recapitulate laminin adhesion/migration cues on the material surface. CRITICAL-this peptide carries one unpaired free N-terminal Cys thiol; its oxidation risk is the defining physicochemical feature that distinguishes it from ordinary adhesion peptides, so solutions and storage must follow thiol-peptide practice (inert gas, oxidant exclusion, no metal ions, fresh preparation, no repeated freeze-thaw). | ECM/basement membrane biology, cell adhesion and migration, tissue-engineering scaffold/hydrogel peptide functionalization, neurite outgrowth/nerve regeneration, tumor-cell adhesion and metastasis, angiogenesis, biomaterial surface immobilization, regenerative medicine | 67 kDa laminin receptor (67LR / LAMR1 / RPSA / p40 ribosome-associated protein); core motif YIGSR; N-terminal Cys thiol-maleimide covalent immobilization; downstream cell adhesion/migration and neurite-outgrowth signaling |
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