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| Description | CD36 Peptide P (139-155) corresponds to a second key human CD36 extracellular region involved in recognition of oxLDL, thrombospondin and malaria-infected erythrocytes. Used together with the 93-110 fragment to map distinct CD36 ligand epitopes and study lipid metabolism and innate immune recognition. |
| Peptide purity (HPLC) | ≥95% |
| CAS No. | 143257-74-3 |
| Structure type | Linear 17-mer (CD36 139-155, Cys-conjugated) |
| Solubility | Readily soluble in water/PBS; minor cosolvent for hydrophobic sequence |
| Storage | Powder, −20°C, dry, light-protected |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Cys-CD36 (139-155) (human CD36 scavenger receptor extracellular domain residues 139-155, N-terminally cysteine-conjugated for carrier/gold/solid-phase coupling) | Cys-CD36(139-155); CNLAVAAASHIYQNQFVQ; H-Cys-Asn-Leu-Ala-Val-Ala-Ala-Ala-Ser-His-Ile-Tyr-Gln-Asn-Gln-Phe-Val-Gln-OH; CD36 ligand peptide P (139-155); OKM5 antibody epitope peptide; oxidized LDL binding-region peptide; CAS 143257-74-3 | CD36 scavenger receptor, CD36 ligand peptide, oxidized LDL binding, long-chain fatty acids, Cys-conjugated peptide, OKM5 antibody epitope, atherosclerosis research | Linear 18-mer (extra N-terminal Cys + CD36 extracellular residues 139-155, NLAVAAASHIYQNQFVQ), H-CNLAVAAASHIYQNQFVQ-OH; the N-terminal Cys provides a free thiol (-SH) for maleimide/iodoacetamide coupling; the N-terminal alpha-amine belongs to the Cys itself (free), and the C-terminus is a free carboxyl (free acid, -COOH); net charge near neutral (only 1 His side chain ~10% protonated at pH 7; N-terminus +1 and C-terminus -1 nearly cancel); contains 1 Cys (prone to oxidative disulfide dimerization); the sequence contains 4 consecutive Ala, 2 Val, 1 Ile, 2 Phe-more hydrophobic than the 93-110 peptide; the CD36 139-155 region is a key OKM5 monoclonal antibody epitope and another functional site for oxLDL/collagen binding | C87H133N25O26S | 1975.96 | 1977.23 | Free acid (C-terminal -COOH); TFA/acetate forms available on request; CAS 143257-74-3 | 18 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-CD36P139-01 | White to off-white powder | Store at -20°C, sealed, desiccated, protected from light (~2 years). Aliquot to avoid repeated freeze-thaw. Contains 1 Cys thiol-protect from oxidative dimerization (store under inert gas or with a trace reducing agent). | 2–8°C for up to ~1 month; working aliquots at -20°C, protected from light; stable for shipping at ambient. | Moderately-to-strongly hydrophobic (consecutive Ala/Val/Ile/Phe residues); poorer water solubility than the 93-110 peptide. Pre-dissolve in a small volume of DMSO or buffer containing 0.1% NH4OH/acetic acid, then dilute in neutral PBS to the desired concentration. No acidic/basic cluster-overall near-neutral. The Cys thiol oxidizes readily in air-prepare fresh; use TCEP/DTT immediately before use if reduction is needed. Typical uses: (1) inhibiting OKM5 anti-CD36 monoclonal antibody immunoadsorption; (2) epitope mapping of CD36 extracellular domain in tandem with CD36(93-110)-Cys; (3) competitive studies of oxLDL/collagen/TSP-1 binding to distinct CD36 regions; (4) as an immunogen peptide coupled to carriers for generating 139-155-region-specific antibodies. | solid stable for ~2 years at -20°C, sealed and desiccated; contains Cys-store in desiccator/inert gas. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-CD36P139-01 | Functional peptide from the extracellular domain of human CD36 scavenger receptor (residues 139-155, N-terminal Cys conjugation); blocks OKM5 antibody immunoadsorption and participates in oxLDL/collagen binding-paired with the 93-110 peptide for CD36 epitope mapping and ligand-competition studies. | The CD36 (SCARB3) extracellular domain is a large, heavily glycosylated loop of ~1000 residues anchored by two transmembrane helices, bearing multiple ligand-binding and antibody epitopes. The 139-155 region (NLAVAAASHIYQNQFVQ) is a second well-studied functional site: it is rich in hydrophobic residues (consecutive Ala-Ala-Ala, Val, Ile, Phe), in stark contrast to the polar/acidic 93-110 region, and is thought to participate in recognition of the hydrophobic lipid moiety of oxidized LDL as well as collagen binding. The extra N-terminal Cys provides a thiol handle for maleimide-mediated coupling to carrier proteins, gold particles, or solid supports. One of the most important applications of this peptide is inhibition of OKM5-series anti-CD36 monoclonal antibody immunoadsorption-OKM5 is a classic tool antibody for studying CD36 function (platelet aggregation, macrophage oxLDL uptake, anti-angiogenesis), and its epitope lies near residues 139-155. Used together with CD36(93-110)-Cys, the two peptides occupy independent extracellular epitopes, enabling competition-binding experiments to determine whether TSP-1, oxLDL, collagen, or Plasmodium-infected erythrocytes bind to which region, and whether allosteric coupling exists between the sites. The peptide can also serve as an immunogen (coupled to KLH/BSA) for raising polyclonal/monoclonal antibodies against the 139-155 region, used for CD36 tissue localization, Western blotting, and functional blocking. Research areas include lipid uptake by foam cells in atherosclerotic plaques, platelet collagen-receptor function, endothelial TSP-1-CD36 anti-angiogenic signaling, long-chain fatty acid transport in cardiac/adipose tissue, and endothelial adhesion of malarial-infected erythrocytes. | Atherosclerosis, foam cell/oxLDL uptake, platelet collagen aggregation, OKM5 antibody epitope, CD36 epitope mapping, long-chain fatty acid transport, TSP-1-CD36 angiogenesis, immunogen peptide/antibody production | CD36 (SCARB3) extracellular domain residues 139-155; inhibits OKM5 monoclonal antibody immunoadsorption; participates in oxLDL/collagen binding; independent from the 93-110 epitope |
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