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| Description | CD36 Peptide P (93-110) corresponds to the human CD36 extracellular region that binds oxidized LDL, long-chain fatty acids and apoptotic cells; an introduced Cys enables oriented immobilization. It is used to study CD36-mediated lipid uptake, foam-cell formation, atherosclerosis and inflammatory signaling. |
| Peptide purity (HPLC) | ≥95% |
| CAS No. | 143257-75-4 |
| Structure type | Linear 18-mer (CD36 93-110, Cys-conjugated) |
| Solubility | Readily soluble in water/PBS; minor cosolvent for hydrophobic sequence |
| Storage | Powder, −20°C, dry, light-protected |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| CD36 Peptide P (93-110), Cys conjugated (human CD36 scavenger receptor extracellular domain residues 93-110, C-terminally cysteine-conjugated for carrier/gold/solid-phase coupling) | CD36 (93-110)-Cys; YRVRFLAKENVTQDAEDNC; H-Tyr-Arg-Val-Arg-Phe-Leu-Ala-Lys-Glu-Asn-Val-Thr-Gln-Asp-Ala-Glu-Asp-Asn-Cys-OH; CD36 ligand peptide P; thrombospondin-1 (TSP-1) binding-site peptide; oxidized LDL binding-region peptide; CAS 143257-75-4 | CD36 scavenger receptor, CD36 ligand peptide, oxidized LDL binding, long-chain fatty acid uptake, thrombospondin-1 (TSP-1), Cys-conjugated peptide, antibody-blocking peptide, atherosclerosis research | Linear 19-mer (CD36 extracellular residues 93-110, YRVRFLAKENVTQDAEDN, plus an extra Cys at the C-terminus), H-YRVRFLAKENVTQDAEDNC-OH; free N-terminal amine and free C-terminal carboxyl (free acid, -COOH); the C-terminal Cys provides a free thiol (-SH) for maleimide/iodoacetamide coupling to KLH/BSA carrier proteins, gold particles, or solid-phase supports; net charge approximately -1 (R, R, K side chains +3; E, D, E, D side chains -4; N-terminus +1, C-terminus -1); contains 1 Cys (prone to oxidation/disulfide dimerization-store reduced and aliquoted); contains 2 Arg, 1 Lys, 4 acidic residues; CD36 is a class B scavenger receptor (SCARB3), and the 93-110 region is a key functional site for TSP-1 binding and oxidized LDL recognition | C96H151N29O33S | 2270.08 | 2271.49 | Free acid (C-terminal -COOH); TFA/acetate forms available on request; CAS 143257-75-4 | 19 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-CD36P93-01 | White to off-white powder | Store at -20°C, sealed, desiccated, protected from light (~2 years). Aliquot to avoid repeated freeze-thaw. Contains 1 Cys thiol-protect from oxidative dimerization (store under inert/argon gas or with a trace reducing agent). | 2–8°C for up to ~1 month; working aliquots at -20°C, protected from light; stable for shipping at ambient. | Moderately hydrophilic peptide with 4 acidic and 3 basic residues; soluble in water or neutral buffer (PBS, Tris-HCl, pH 7.0-7.4) to mg/mL; if solubility is limited, use a small volume of DMSO or acetic acid (pH 3-4) as co-solvent. The C-terminal Cys thiol readily oxidizes to disulfide dimer in air-prepare fresh and minimize air exposure; use TCEP or DTT immediately before use if reduction is needed. Typical uses: (1) blocking immunoadsorption of CD36 antibodies (e.g., OKM5 series); (2) competitively inhibiting CD36 binding to immobilized TSP-1 and oxidized LDL; (3) partially inhibiting collagen-induced platelet aggregation; (4) as an immunogen peptide coupled to carrier proteins for generating site-specific CD36 antibodies. | solid stable for ~2 years at -20°C, sealed and desiccated; contains Cys-store in desiccator/inert gas to prevent oxidation. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-CD36P93-01 | Functional peptide from the extracellular domain of human CD36 scavenger receptor (residues 93-110, C-terminal Cys conjugation); blocks CD36 binding to TSP-1/oxidized LDL and competitively inhibits collagen-induced platelet aggregation-used in atherosclerosis, lipid uptake, and CD36 signaling research. | CD36 (also known as SCARB3, class B scavenger receptor) is a transmembrane glycoprotein expressed on platelets, monocyte/macrophages, endothelial cells, adipocytes, cardiomyocytes, and retinal pigment epithelium. It serves as a multifunctional receptor for oxidized low-density lipoprotein (oxLDL), long-chain free fatty acids (LCFA), thrombospondin-1 (TSP-1), collagens, apoptotic cells, and Plasmodium falciparum-infected erythrocytes (via PfEMP1-mediated sickle red-cell adhesion). The CD36 extracellular domain contains multiple ligand-binding regions; residues 93-110 (YRVRFLAKENVTQDAEDN) were identified by Leung et al. (JBC, 1997) and subsequent studies as a key functional site: this peptide blocks CD36 binding to immobilized TSP-1, partially inhibits collagen-induced platelet aggregation, and participates in oxLDL recognition. The extra C-terminal Cys provides a thiol handle for maleimide-mediated covalent coupling to KLH/BSA carrier proteins (for immunization and site-specific antibody production), colloidal gold particles (for EM localization), or ELISA/SPR solid supports. Used in tandem with CD36(139-155)-Cys, this peptide covers two independent extracellular ligand-binding epitopes, allowing researchers to map the spatial binding sites and competition among TSP-1, oxLDL, and collagen. Research areas include atherosclerotic foam-cell formation, cardiac fatty-acid metabolism and lipotoxic cardiomyopathy, platelet aggregation and thrombosis, TSP-1-CD36 anti-angiogenic signaling, malarial immunopathology (sickle red-cell adhesion), and adipose-tissue energy metabolism. | Atherosclerosis, foam cell formation, oxidized LDL uptake, platelet aggregation/thrombosis, TSP-1-CD36 anti-angiogenic axis, long-chain fatty acid metabolism, antibody-blocking/immunogen peptides, Plasmodium-infected erythrocyte adhesion | CD36 (SCARB3) extracellular domain residues 93-110; competitively inhibits CD36 binding to TSP-1 and oxLDL; partially inhibits collagen-induced platelet aggregation |
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