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| Description | A heterologous mimotope (1040-31) selected on BDC2.5, binding NOD MHC-II I-Ag7 to activate pathogenic Th cells; TFA salt; used for type-1-diabetes tolerance and β-cell destruction. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| BDC2.5 Mimotope 1040-31 TFA (Mimotope peptide of the diabetogenic NOD BDC2.5 CD4+ T cell clone, TFA salt) | BDC2.5 mimotope 1040-31, p31, YVRPLWVRME, BDC2.5 TCR agonist peptide, I-Ag7-restricted peptide | Type 1 diabetes, T cell mimotope, Autoimmunity, BDC2.5 T cell clone, pMHC-II immune tolerance | YVRPLWVRME (H-Tyr-Val-Arg-Pro-Leu-Trp-Val-Arg-Met-Glu-OH, linear 10-mer, free N-terminal amino group / free C-terminal carboxyl) | C63H97N17O14S | 1347.71 | 1348.63 | TFA salt (as labeled) | 10 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-BDC31-01 | white to off-white powder | Store frozen below -20°C, protected from light, dry and sealed; contains 1 Met (oxidation-prone) and 1 Trp (light-sensitive); nitrogen blanketing and amber vial recommended; powder stable for 2-3 years at -20°C | Store sealed, dry and protected from light at 4°C, use within 2-4 weeks; after reconstitution, aliquot and store at -20°C, avoid repeated freeze-thaw | Hydrophobic peptide (~60% hydrophobic residues); dissolve first in a small amount of DMSO, then dilute with sterile water or PBS (pH 7.4) to working concentration; 1 Met is readily oxidized to methionine sulfoxide - degas solutions and avoid oxidants; 1 Trp is light-sensitive - protect from light during handling and storage; aliquot to avoid repeated freeze-thaw | powder stable for 2-3 years at -20°C when dry, sealed and protected from light; protect from moisture and light; aliquot promptly after opening and keep in a desiccator |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-BDC31-01 | BDC2.5 Mimotope 1040-31 (YVRPLWVRME, literature alias p31, TFA salt), a high-affinity MHC-II (I-Ag7)-restricted mimotope selected from combinatorial peptide libraries for the diabetogenic NOD BDC2.5 CD4+ T cell clone, for T1D autoimmunity and antigen-specific tolerance studies. | This peptide is mimotope 1040-31 (YVRPLWVRME, literature alias p31), selected from a combinatorial peptide library for the diabetogenic CD4+ T cell clone BDC2.5 in NOD mice; it is MHC-II (I-Ag7)-restricted and a strong agonist ligand for the BDC2.5 TCR. It shares the conserved C-terminal core PLWVRME with BDC2.5 mimotope 1040-63 (RTRPLWVRME), differing only at N-terminal positions 1-3 (YVR vs RTR). It is widely used in studies of type 1 diabetes immunopathology, autoreactive T cell activation and epitope recognition; p31-I-Ag7 dimers can induce antigen-specific immune tolerance and prevent adoptively transferred diabetes (Masteller et al. 2003). Note: this product has the sequence YVRPLWVRME (10-mer); it must not be confused with the 1040-63 sequence RTRPLWVRME. | Type 1 diabetes immunology, Autoreactive T cells, Epitope mimetics, Antigen-specific immune tolerance, MHC-II molecules | MHC-II (I-Ag7); BDC2.5 T cell receptor (TCR) |
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