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| Description | A heterologous mimotope (1040-63) selected on the BDC2.5 T-cell hybridoma; binds NOD MHC-II I-Ag7 to activate pathogenic Th1 cells. A standard model peptide for type-1-diabetes autoimmunity and β-cell destruction. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| BDC2.5 Mimotope 1040-63 | BDC2.5 mimotope 1040-63, RTRPLWVRME, BDC2.5 TCR agonist peptide | Type 1 diabetes, T cell mimotope, Autoimmunity, BDC2.5 T cell clone | RTRPLWVRME (H-Arg-Thr-Arg-Pro-Leu-Trp-Val-Arg-Met-Glu-OH, linear 9-mer) | C59H98N20O14S | 1342.73 | 1343.62 | Free acid (per published formula) | 9 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-BDC25-01 | powder, white to off-white (AnaSpec, purity >=95% HPLC; CAS 329696-53-9) | Store frozen below -20 C, protected from light, dry and tightly sealed | Store at 4 C sealed and dry, use within 2-4 weeks; after reconstitution, aliquot and store at -20 C | Freely soluble in water (3 Arg residues, net charge +2); reconstitute in sterile water or PBS; contains 1 Trp (light-sensitive) and 1 Met (oxidation-prone), so protect from light, deoxygenate solutions, avoid oxidants and aliquot to avoid repeated freeze-thaw | powder stable long-term (approx. 3 years) at -20 C, dry, light-protected and sealed; keep moisture-proof; Met is oxidation-sensitive and Trp is light-sensitive, avoid prolonged air/light exposure |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-BDC25-01 | BDC2.5 Mimotope 1040-63 (RTRPLWVRME), a high-affinity mimotope of the autoreactive BDC2.5 CD4+ T cell clone in NOD mouse type 1 diabetes, for autoreactive T cell activation, antigen recognition and MHC-II-restriction studies. | This peptide is the BDC2.5 mimotope 1040-63 (CAS 329696-53-9; AnaSpec). BDC2.5 is a diabetogenic CD4+ T cell clone in NOD mice that recognizes an islet beta-cell self antigen (the WE14 region of chromogranin A) in an MHC-II (I-Ag7)-restricted manner; 1040-63 (RTRPLWVRME) is a high-affinity agonist mimotope selected from combinatorial peptide libraries that potently activates BDC2.5 T cells in vitro. It is widely used in studies of T1D immunopathology, T cell epitope/agonist screening, autoreactive T cell quantification and adoptive transfer. | Type 1 diabetes immunology, Autoreactive T cells, Epitope mimetics, T cell activation | MHC-II (I-Ag7); BDC2.5 T cell receptor (TCR) |
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