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| Description | TYVPANASL binds the corresponding MHC-I and is recognized by TCRs; TFA salt for epitope-specific T-cell responses, tetramer preparation and immune-recognition studies. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| TYVPANASLFA | TYVPANASLFA, neu p66 extended peptide, rNEU 66-76 | Tumor epitope peptide, HER2/neu p66 extended epitope, CTL epitope, Cancer vaccine research | TYVPANASLFA (H-Thr-Tyr-Val-Pro-Ala-Asn-Ala-Ser-Leu-Phe-Ala-OH, linear 11-mer) | C54H80N12O16 | 1152.58 | 1153.30 | TFA salt (typical) | 11 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-TYVPANASLFA-01 | powder, white to off-white (no public supplier product page exists for this extended 11-mer; appearance described per conventional synthetic peptides) | Store frozen below -20 C, protected from light, dry and tightly sealed | Store at 4 C sealed and dry, use within 2-4 weeks; after reconstitution, aliquot and store at -20 C | Hydrophobic peptide (~64% hydrophobic residues): first dissolve in DMSO (gentle heating may help), then dilute with water or buffer; contains one Tyr residue, keep protected from light to prevent photo-oxidation; aliquot to avoid repeated freeze-thaw. No supplier solubility data exists for this 11-mer; above is derived from structure | powder is stable long-term at -20 C, dry, light-protected and sealed; keep moisture-proof; Tyr-containing, must be protected from light |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-TYVPANASLFA-01 | C-terminally extended peptide of the rat HER2/neu p66 CTL epitope (TYVPANASL, neu 66-74, H-2Kd/BALB/c), approx. neu 66-76, for HER2-positive cancer vaccine and CD8+ T cell immunity studies. | This 11-mer is a C-terminal extension (approx. residues 66-76 of rat HER2/neu) of the immunodominant CD8+/CTL epitope p66 (TYVPANASL, neu residues 66-74, H-2Kd-restricted in BALB/c mice; NIH tetramer nomenclature Kd/rNEU.p66.TYVPANASL; parent 9-mer TYVPANASL corresponds to CAS 921621-38-7), retaining the core minimal epitope TYVPANASL. It is used for immunotherapy and vaccine research in HER2-positive breast cancer (J-LEAPS/J-HER vaccines, T7 phage multivalent nanoparticle vaccines, dendritic cell vaccines combined with anti-PD-1), studying epitope processing/presentation and therapeutic CD8 T cell responses. No public supplier product page exists for this extended 11-mer; its physicochemical parameters (appearance, solubility, storage) are derived from structure, while the immunological background is based on published literature on the 9-mer parent epitope. | Tumor immunology, HER2/neu vaccine research, CD8+ T cell detection, Cancer vaccine development | H-2Kd (MHC-I presentation, core 9-mer parent epitope TYVPANASL); T cell receptor (TCR) |
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