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| Product name | CAS:330456-40-1;Tau Peptide (277-291) |
| Sequence | IINKKLDLSNVQSKC |
| Three letter sequence | Ile-Ile-Asn-Lys-Lys-Leu-Asp-Leu-Ser-Asn-Val-Gln-Ser-Lys-Cys |
| Peptide purity (HPLC, %) | 95%/99% |
| Molecular formula | C73H131N21O23S |
| Molecular weight (Da) | 1703.01 |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Amino Acid Full Name Sequence | Molecular Formula | Exact Molecular Weight (Da) | Average Molecular Weight (Da) | Terminal Modification - N-terminus | Terminal Modification - C-terminus | Sequence Length (aa) |
| Tau Peptide (277-291) | #Tau(277-291) #Microtubule-binding tau fragment; #Neurofibrillary tangle peptide; #Tau phosphorylation research | Tau protein phosphorylation, microtubule assembly regulation, neurofibrillary tangles, Alzheimer's disease, neurodegeneration, kinase substrate | Serine-Serine-Serine-Proline-Serine-Serine-Serine-Serine-Proline-Serine-Serine-Serine-Proline-Serine-Serine | C₆₉H₁₀₄N₂₆O₃₃ | 1816.741 | 1817.71 | Unmodified | Free carboxyl group | 15 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-Tau01 | White powder | -20℃, sealed away from light, aliquoted, avoid repeated freeze-thaww | 2-8℃, use within 1 month; prepare fresh before experiment | Stable for 24 h at 4℃ | 3 years at -20℃, 2 years at 4℃ |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Target / Receptor |
| PEP-Tau01 | Tau(277-291) is a microtubule-binding fragment of human tau protein with abundant serine phosphorylation sites, applied in tau kinase and neurofibrillary pathology research | Tau Peptide (277-291) belongs to the core repeat domain of microtubule-associated tau protein, rich in Ser-Pro phosphorylation motifs, acting as natural substrate for key tau kinases including GSK-3β and CDK5. Under physiological conditions, it stabilizes neuronal microtubule assembly; abnormally hyperphosphorylation abolishes its microtubule-binding capacity and triggers aggregation into neurofibrillary tangles (NFTs). It is widely used for in vitro assays: tau kinase activity screening, phosphorylation modification mechanism, pathological study of Alzheimer's disease & frontotemporal dementia, anti-tau aggregation drug evaluation, suitable for neuropathology and protein kinase pharmacology research | Neurodegenerative diseases, Alzheimer's disease, tau phosphorylation, kinase screening, microtubule dynamics, neurofibrillary tangles | GSK-3β, CDK5, tubulin, tau oligomers |
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