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| Product name | CAS:1003007-59-7:Tau Peptide (306-317) |
| Sequence | VQIVYKPVDLSK |
| Three letter sequence | Val‑Gln‑Ile‑Val‑Tyr‑Lys‑Pro‑Val‑Asp‑Leu‑Ser‑Lys |
| Peptide purity (HPLC, %) | 95%/99% |
| Molecular formula | C₆₅H₁₀₉N₁₅O₁₈ |
| Molecular weight (Da) | 1388.65 |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Amino Acid Full Name Sequence | Molecular Formula | Exact Molecular Weight (Da) | Average Molecular Weight (Da) | Terminal Modification - N-terminus | Terminal Modification - C-terminus | Sequence Length (aa) |
| Tau Peptide (306-317) | #Tau(306-317) #Tau microtubule-binding repeat fragment; #PHF aggregation core peptide; #Tau phosphorylation pathology research | Tau aggregation, paired helical filament (PHF) formation, microtubule assembly, kinase substrate, Alzheimer's disease, neurodegeneration | Serine-Lysine-Valine-Serine-Serine-Proline-Serine-Serine-Serine-Serine-Proline-Serine | C₅₄H₉₀N₂₀O₂₇ | 1414.635 | 1415.42 | Unmodified | Free carboxyl group | 12 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-Tau02 | White powder | -20℃, sealed away from light, aliquoted, avoid repeated freeze-thaw | 2-8℃, use within 1 month; prepare fresh before experiment | Stable for 24 h at 4℃ | 3 years at -20℃, 2 years at 4℃ |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Target / Receptor |
| PEP-Tau02 | Tau(306-317) is the core PHF6 aggregation fragment of human Tau protein with abundant phosphorylatable serine residues, used to construct in vitro neurofibrillary tangle models | Tau Peptide (306-317) is the core PHF6 sequence within the microtubule-binding domain of Tau protein, the key region mediating tau oligomerization, paired helical filaments (PHF) and neurofibrillary tangle assembly. The sequence contains multiple Ser-Pro kinase recognition motifs, serving as canonical substrate for tau-related kinases including GSK-3β and CDK5. Under physiological conditions, it binds and stabilizes neuronal microtubules; hyperphosphorylation triggers dissociation from microtubules and spontaneous self-aggregation. Widely applied in in vitro assays for tau aggregation inhibitor screening, kinase activity measurement, pathological mechanism study of Alzheimer's disease & frontotemporal dementia, neurotoxicity cell models, suitable for neuropathology and protein modification pharmacology research | Neurodegenerative diseases, Alzheimer's disease, tau protein aggregation, paired helical filaments (PHF), kinase screening, microtubule dynamics | GSK-3β, CDK5, Tubulin, Tau homo-oligomers |
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