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| Description | Alloferon 2 (CAS: 347884-62-2) is a 12-residue immunomodulatory antiviral peptide isolated from immune-challenged blowfly (Calliphora vicina) hemolymph, sequence GVSGHGQHGVHG. Molecular formula C46H69N19O15, MW 1128.18 Da. Alloferon 2 differs from Alloferon 1 (HGVSGHGQHGVHG, 13 residues) only by one N-terminal His, with high histidine content (4/12 = 33%). Alloferons are linear, nonglycosylated, slightly basic oligopeptides with no teratogenic, embryotoxic, or mutagenic effects; they induce interferon synthesis in human leukocytes, show antiviral activity against herpes simplex virus, and exhibit antitumor immunomodulatory activity. Their sequence is homologous to influenza B virus precursor protein. Alloferon 2 is a tool for studying insect innate immunity, histidine-rich peptide immunomodulation, and antiviral immunotherapy. |
| Structure type | Linear 12-mer (blowfly immune hemolymph histidine-rich immunomodulatory antiviral peptide) |
| Solubility | Readily soluble in water, dilute acetic acid |
| Storage | Powder -20C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Alloferon 2 | Alloferon 2 insect peptide; blowfly antiviral peptide | Antiviral peptide, immunomodulatory, interferon-inducing, insect-derived peptide, anticancer | Natural active peptide isolated from blowfly larval hemolymph, linear cationic peptide; exerts antiviral activity via inducing host interferon production, with combined immunomodulatory and anticancer effects | C₆₄H₉₉N₂₁O₁₆ | 1461.75 | ~1462.6 | Free peptide | 13 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-ALL02 | White powder | Store at -20°C, sealed, dry and protected from light. Aliquot for storage. | Stable for 1 month at 2–8°C in sealed dry condition; stable for shipping at ambient temperature. | Stable for 7 days at 4°C. Soluble in water and physiological buffers. Linear short peptide is sensitive to proteases and prone to degradation in aqueous solution; prepare fresh before use. | Stable for 2 years at -20°C, dry and protected from light. |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-ALL02 | Alloferon 2 insect peptide with interferon-inducing antiviral activity | Alloferon 2 is a natural active short peptide isolated from blowfly larval hemolymph, a linear cationic peptide. It exerts broad-spectrum antiviral activity by activating host immune cells to induce interferon-α and interferon-γ production, inhibiting herpes virus, influenza virus and others. It also has immunomodulatory and anticancer effects, serving as a lead for developing novel antiviral immunomodulators. | Insect-derived peptides, antiviral research, interferon induction, immunomodulation, anticancer | Interferon secretion induction; host immune activation; viral replication inhibition |
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