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| Product Name | CAS:872454-31-4:Delparantag |
| Description | Delparantag (development code PMX-60056) is a new-generation highly potent heparin neutralizing reversal agent. It binds with high affinity to the pentasaccharide core sequence of unfractionated heparin (UFH) and low-molecular-weight heparin (LMWH), sterically blocks the binding of heparin to antithrombin III, rapidly neutralizes anticoagulant activity and restores coagulation function. Its neutralization efficiency is superior to protamine, especially for LMWH. Applied in cardiovascular surgery heparin reversal, heparin overdose rescue, and anticoagulant mechanism research. |
| Peptide Purity (HPLC, %) | 95% / 98% / 99% |
| Molecular Formula | C₅₆H₇₉N₁₃O₁₂ |
| Molecular Weight (Da) | 1126.31 |
| Structure type | Polyarylamide heparin-binding derivative, polycationic backbone |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Structure Type | Target |
| Delparantag | Delparantag; PMX-60056; Heparin reversal agent; CAS 872454-31-4 | Heparin neutralization,Anticoagulant reversal,UFH/LMWH neutralization,Superior to protamine,Cardiovascular surgery,Coagulation recovery | 4 methoxysalicylamide units linked via lysine side-chain amide bonds, polycationic aromatic scaffold | C₅₆H₇₉N₁₃O₁₂ | 1125.6 | 1126.31 | Non-peptidic arylamide derivative | Heparin pentasaccharide sequence / Heparin-antithrombin complex |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-DEL003 | white powder | Store at -20℃, sealed, dry & protected from light, aliquoted; avoid repeated freeze-thaw cycles | Stable for 2 years at 2-8℃ sealed & dry; short-term stable at room temperature during shipping | Stable for 72 h at 4℃; stable for 1 month at -20℃ in aliquots. **Extremely poor water solubility as free base; DMSO required for solubilization; moderate solubility as hydrochloride salt**. Aromatic amide backbone stable to acid/base, not degraded by peptidases | Stable for over 3 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-DEL003 | Potent heparin neutralizing reversal agent that specifically binds heparin pentasaccharide sequence for rapid coagulation recovery, superior to protamine | Delparantag is a structurally optimized polycationic aromatic amide heparin neutralizer. Through multiple positively charged side chains and hydrophobic aromatic groups in the molecule, it synergistically binds to the negatively charged pentasaccharide core sequence on the heparin surface, forming a stable complex. It sterically blocks the binding of heparin to antithrombin III (AT III), rapidly neutralizes the anticoagulant activity of heparin and restores endogenous coagulation function. Compared with classic protamine, it has higher neutralization efficiency per unit mass, more thorough neutralization effect on low-molecular-weight heparin, can effectively neutralize protamine-resistant heparin fragments, and has lower risk of allergic reactions. This molecule has fast onset and short half-life in vivo, and can precisely regulate the degree of anticoagulation reversal. It serves as a core tool compound for cardiovascular surgery heparin neutralization, heparin overdose rescue, anticoagulant pharmacodynamic evaluation, and LMWH reversal protocol optimization.Cardiovascular surgery research,Anticoagulant reversal study,Heparin overdose model,LMWH research,Coagulation function evaluation,Anticoagulant | Cardiovascular surgery research,Anticoagulant reversal study,Heparin overdose model,LMWH research,Coagulation function evaluation,Anticoagulant drug development | Heparin/LMWH pentasaccharide sequence; Heparin-antithrombin III complex blockade; Coagulation function recovery pathway |
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