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| Product Name | CAS:134861-34-0:GE 2270A |
| Description | GE 2270A is a novel thiopeptide antibiotic produced by rare Actinomycetes fermentation. It specifically binds to bacterial elongation factor EF-Tu and blocks the protein synthesis elongation process. It exhibits potent antibacterial activity against multidrug-resistant Gram-positive bacteria such as MRSA and VRE. Applied in drug-resistant infection, antibacterial mechanism research and novel antibiotic development. |
| Peptide Purity (HPLC, %) | 90%/95%/98% |
| Molecular Formula | C₅₄H₄₆N₁₂O₁₀S₆ |
| Molecular Weight (Da) | ~1191.42 |
| Structure type | Polyheterocyclic thiopeptide cyclic peptide antibiotic |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Full Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Cyclization Mode | Structure Type |
| GE 2270A | GE2270A; Thiopeptide antibiotic; EF-Tu inhibitor; CAS 134861-34-0 | Anti-multidrug-resistant bacteria,Protein synthesis inhibition,EF-Tu targeting,MRSA/VRE activity,Thiopeptide cyclic peptide,Novel antibiotic development | Macrocyclic peptide backbone embedded with multiple thiazole/oxazole heterocycles, rigid conjugated structure | C₅₄H₄₆N₁₂O₁₀S₆ | 1190.21 | 1191.42 | Peptide bond + heterocycle macrocyclization | Non-ribosomal thiopeptide antibiotic |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-GE27001 | Pale yellow to yellow amorphous powder | Store at -20℃, strictly protected from light, sealed and dry, aliquoted; avoid high temperature and acid/base | Solid powder stable for 2 years at 2-8℃ sealed and dry; stock solutions prepared in DMSO or chloroform | Stable for 72 h at 4℃ under anhydrous & dark conditions. Prone to precipitation in aqueous phase; **aqueous solution extremely unstable, must be prepared freshly before use**. **Extremely poor water solubility, organic solvents such as DMSO required**. Heterocycles prone to ring-opening degradation under acid/base and high temperature | Stable for 2 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-GE27001 | Thiopeptide cyclic peptide antibiotic that targets EF-Tu to block bacterial protein synthesis, potent against multidrug-resistant Gram-positive bacteria | GE 2270A is a typical thiazolyl thiopeptide natural product produced via non-ribosomal peptide synthesis pathway, with a highly rigid macrocyclic conjugated structure. It specifically binds to the GTPase domain of bacterial elongation factor EF-Tu, inhibits the GTP hydrolysis activity of EF-Tu, and blocks the transport of aminoacyl-tRNA to the ribosomal A site, thereby inhibiting the elongation phase of bacterial protein synthesis and ultimately leading to bacterial growth arrest and death. This molecule exhibits nanomolar antibacterial activity against Gram-positive bacteria such as Staphylococcus aureus, Streptococcus and Enterococcus, and is also effective against clinical drug-resistant strains such as MRSA and VRE, with no cross-resistance to existing antibiotics. It serves as a core tool compound for drug-resistant infection research, novel antibiotic target validation, and thiopeptide SAR analysis. | Drug-resistant infection research,Novel antibiotic development,Bacterial protein synthesis mechanism,Ribosome function study,MRSA/VRE research,Microbial pharmacology study | Bacterial elongation factor EF-Tu; Protein synthesis elongation blockade pathway; Gram-positive bacteria growth inhibition pathway |
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