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| Product Name | CAS:239480-61-6:NBI-6024 |
| Description | NBI-6024 is a site-modified proinsulin T cell epitope peptide. It induces immune tolerance in insulin-specific autoreactive T cells, inhibits autoimmune attack on pancreatic β cells, and delays the progression of type 1 diabetes. Applied in autoimmune diabetes, immune tolerance mechanism and peptide vaccine research. |
| Peptide Purity (HPLC, %) | 95% / 98% / 99% |
| Theoretical molecular weight | ~2.2 kDa |
| Modification type | Amino acid site modification to optimize MHC binding properties |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Full Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Terminal Modification | Sequence Length (aa) |
| NBI-6024 | NBI-6024; Proinsulin tolerance peptide; Type 1 diabetes peptide vaccine; CAS 239480-61-6 | Immune tolerance induction,Autoimmunity inhibition,Type 1 diabetes study,T cell epitope peptide,Peptide vaccine,Islet protection | Proinsulin-derived modified epitope peptide with site mutations optimized for MHC class II binding | Large polypeptide, no precise small-molecule formula; subject to actual batch MS | - | ~2200 (theoretical) | Native free termini, no chemical modification | ~20 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-NBI001 | white powder | Store at -20℃, sealed, dry & protected from light, aliquoted; avoid repeated freeze-thaw cycles | Solid powder stable for 1 year at 2-8℃ sealed and dry; prepare aqueous solutions in low-binding tubes | Stable for 72 h at 4℃ under sterile conditions; stable for 1 month at -20℃ in aliquots. **Good water solubility, freely soluble in water and physiological buffer**. Peptide prone to adsorb to plastic consumable surfaces; low-binding centrifuge tubes recommended. Repeated freeze-thaw leads to epitope conformational change | Stable for 2 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-NBI001 | Modified proinsulin T cell epitope peptide that induces autoimmune tolerance and delays type 1 diabetes progression | NBI-6024 is a modified peptide optimized based on the proinsulin B chain T cell epitope. Through key amino acid site mutations, it alters the binding mode with MHC class II molecules, inducing autoreactive T cells toward tolerance rather than activating immune responses. It can be taken up and presented by antigen-presenting cells, induce CD4+ T cell anergy and regulatory T cell expansion, inhibit specific autoimmune attack on pancreatic β cells, reduce β cell destruction, and delay the onset and progression of type 1 diabetes. This peptide serves as a core tool molecule for type 1 diabetes immunotherapy research, T cell tolerance mechanism analysis, peptide vaccine SAR optimization, and autoimmune disease intervention. | Type 1 diabetes study,Autoimmune disease study,Immune tolerance mechanism,T cell epitope research,Peptide vaccine development,Islet biology research | MHC class II molecule-peptide complex; Autoreactive T cell tolerance pathway; Pancreatic β cell immune protection pathway |
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