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| Product name | CAS:1883548-85-3:WAY-181187 oxalate |
| Description | WAY-181187 is a highly selective serotonin 2C (5-HT2C) receptor agonist with blood-brain barrier permeability. It activates central 5-HT2C pathways to exert appetite suppression, anxiolytic and metabolic improvement effects, with extremely low affinity to 5-HT2A/2B receptors. Applied in mechanism research of obesity, anxiety and central nervous pathways. |
| Purity (HPLC, %) | 95%/98%/99% |
| Molecular formula | C₂₆H₃₁ClN₂O₆ (monooxalate) |
| Molecular weight (Da) | 499.00 |
| Salt form | Monooxalate |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Full Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Structure Type | Salt Form |
| WAY-181187 oxalate | WAY-181187 oxalate; WAY 181187; CAS 1883548-85-3 | 5-HT2C receptor highly selective agonist,Central appetite suppression,Anxiolytic research,Metabolic improvement,Low cardiovascular risk,Blood-brain barrier permeable | Indoleethylamine backbone with chloro-methoxy substitution, chiral S-configuration | C₂₆H₃₁ClN₂O₆ (monooxalate) | 498.19 | 499 | Small-molecule indole derivative | Monooxalate |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-WAY001 | white powder | Store at -20℃, strictly protected from light, sealed and dry, aliquoted; avoid high temperature and strong light | Solid powder stable for 1 year at 2-8℃ sealed and dry; stock solutions recommended to be prepared in DMSO | Stable for 72 h at 4℃ in dark; stable for 1 month at -20℃ in aliquots. **Poor water solubility, slightly soluble in water**, DMSO or ethanol required for solubilization. Photooxidation-prone, strict light protection required | Stable for 2 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-WAY001 | Highly selective 5-HT2C receptor agonist with central appetite suppression and anxiolytic effects, no cardiovascular side effects | WAY-181187 is a second-generation highly selective 5-HT2C receptor agonist. The chiral S-configuration precisely matches the receptor binding pocket, with Ki ~1 nM for 5-HT2C, >100-fold selectivity over 5-HT2A and >1000-fold over 5-HT2B, significantly reducing the cardiovascular risk and hallucinogenic side effects of traditional 5-HT agonists. It penetrates the blood-brain barrier, activates 5-HT2C receptors in the hypothalamus and limbic system, suppresses the appetite center, reduces feeding behavior, and regulates mood-related neural circuits for anxiolytic effects. Preclinical studies demonstrate dose-dependent body weight reduction in diet-induced obese models with no obvious central adverse effects. It serves as a classic tool compound for obesity mechanism, anxiety disorders, 5-HT pathway research and novel central metabolic drug development. | Obesity mechanism research,Anxiety disorder research,Serotonin pathway research,CNS drug development,Appetite regulation research,Metabolic disease research | 5-Hydroxytryptamine 2C Receptor (5-HT2CR); Central appetite regulatory pathway; Mood-regulating neural circuits |
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