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| Product name | CAS:2420483-82-3:Pegloxenatide |
| Description | Pegloxenatide is a long-acting glucagon-like peptide-2 (GLP-2) receptor agonist. Amino acid substitutions enhance enzymatic stability, and site-specific PEGylation greatly prolongs in vivo half-life. Applied in mechanism research of short bowel syndrome, chemoradiotherapy-induced intestinal mucosal injury and inflammatory bowel disease. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Theoretical molecular weight | ~32.5 kDa (varies slightly with PEG polydispersity) |
| Modification type | Site-specific mono-PEGylation |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Full Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Average MW (Da) | N-terminal Modification | C-terminal Modification | Sequence Length (aa) |
| Pegloxenatide | Pegloxenatide; PEGylated GLP-2 agonist; CAS 2420483-82-3 | GLP-2 receptor agonist,Intestinal mucosal repair,Short bowel syndrome study,PEG long-acting modification,Intestinal barrier improvement,Once-weekly dosing | Histidine-Glycine-Aspartic acid-Glycine-Serine-Phenylalanine-Serine-Aspartic acid-Glutamic acid-Methionine-Asparagine-Threonine-Isoleucine-Leucine-Aspartic acid-Asparagine-Leucine-Alanine-Alanine-Arginine-Aspartic acid-Phenylalanine-Isoleucine-Asparagine-Tryptophan-Leucine-Isoleucine-Glutamine-Threonine-Lysine(side-chain conjugated PEG linker)-Isoleucine-Threonine-Aspartic acid | Large PEGylated molecule, no precise small-molecule formula | - | ~32500 (with PEG chain) | Native free amine, amino acid substitution for enzyme resistance | Free carboxyl | 33 (core backbone with PEG side-chain modification) |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-PEG001 | white powder | Store at -20℃, sealed, dry & protected from light, aliquoted; avoid repeated freeze-thaw and vigorous shaking | Solid powder stable for 6 months at 2-8℃ sealed and dry; stable for several days at room temperature during shipping | Stable for 7 days at 4℃ under sterile conditions; stable for 3 months at -20℃ in aliquots. **Excellent water solubility, freely soluble in water and physiological buffer**. PEG chain significantly improves molecular stability. Avoid strong acid/base and vigorous shaking to prevent PEG chain cleavage | Stable for over 2 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-PEG001 | PEGylated long-acting GLP-2 receptor agonist promoting intestinal mucosal proliferation and repair, with prolonged half-life for weekly dosing | Pegloxenatide is a new-generation long-acting GLP-2 receptor agonist. Amino acid mutations on the native GLP-2 backbone enhance DPP-IV resistance, and site-specific conjugation of high-molecular-weight polyethylene glycol extends in vivo half-life to approximately 7 days via steric hindrance and reduced renal clearance, supporting once-weekly administration. It specifically activates GLP-2 receptors on intestinal crypt stem cells, triggers the cAMP/PKA signaling pathway, promotes intestinal epithelial cell proliferation, crypt elongation and mucosal barrier repair, increases intestinal absorption area and improves nutrient absorption efficiency. Preclinical studies demonstrate significant alleviation of malabsorption in short bowel syndrome animal models, with superior efficacy to short-acting teduglutide. It serves as a core tool molecule for mechanism research of short bowel syndrome, IBD, chemoradiotherapy-induced intestinal injury, and long-acting peptide drug development. | Short bowel syndrome research,Intestinal mucosal injury repair study,IBD research,Long-acting PEGylated drug development,Intestinal barrier function study,Gastrointestinal endocrinology research | Glucagon-Like Peptide-2 Receptor (GLP-2R); cAMP/PKA signaling pathway; Intestinal epithelial stem cell proliferation and mucosal repair pathway |
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