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| Product name CAS:2130836‑27‑8 | Imsamotide |
| Description | Imsamotide is a new‑generation synthetic immunostimulant. It specifically activates TLR9 receptors, induces innate immune responses, promotes dendritic cell maturation and proinflammatory cytokine release, and enhances antigen‑specific immune responses. Used as a vaccine adjuvant in tumor immunotherapy, infectious disease vaccines and immune mechanism research. |
| Purity (HPLC, %) | 90%/95%/98% |
| Theoretical molecular weight | ~6.8 kDa |
| Modification type | Phosphorothioate backbone modification for enhanced stability |
Products Description
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Modification Type | Structure Length |
| Imsamotide | Imsamotide; Immunostimulatory CpG derivative; TLR9 agonist; CAS 2130836-27-8 | TLR9 receptor agonism,Immune adjuvant,Innate immune activation,Tumor immunotherapy,Vaccine enhancer,Dendritic cell activation | Immunostimulatory backbone with CpG motifs, phosphorothioate modification for nuclease resistance | Large macromolecular derivative, no precise small-molecule formula; subject to actual batch MS | - | ~6800 (theoretical) | Phosphorothioate backbone modification | Multiple immunostimulatory motifs |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-IMS001 | white powder | Store at -20℃, strictly protected from light, sealed and aliquoted; avoid repeated freeze-thaw and nuclease contamination | Solid powder stable for 1 year at 2-8℃ sealed and dry; prepare solutions with nuclease-free water | Stable for 1 month at 4℃ under sterile & nuclease-free conditions; stable for 6 months at -20℃ in aliquots. **Excellent water solubility, freely soluble in nuclease-free water and physiological buffer**. Easily degraded by nucleases; use nuclease-free consumables and buffers. Sensitive to UV light and prone to degradation | Stable for over 2 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-IMS001 | Selective TLR9 agonist that potently activates innate immunity and enhances specific immune responses as a vaccine adjuvant | Imsamotide is a structurally optimized synthetic immunostimulant. After endocytosis by immune cells, it specifically binds to TLR9 receptors on endosomal membranes, triggers downstream NF-κB, MAPK and other signaling pathways, induces activation and maturation of dendritic cells and macrophages, promotes release of proinflammatory cytokines such as IL-6, TNF-α, IFN-α and type I interferons, and comprehensively activates innate immune responses. It also significantly enhances the immunogenicity of co-delivered antigens, elevates antigen-specific antibody and T cell response levels. As a high-efficiency immune adjuvant, it is applied in research fields such as tumor therapeutic vaccines, infectious disease vaccines and allergic immunotherapy, and serves as a core tool molecule for innate immune activation mechanism and TLR signaling pathway research. | Tumor immunity research,Vaccine adjuvant development,Innate immunity mechanism study,TLR pathway study,Infection immunity research,Dendritic cell research | Toll-Like Receptor 9 (TLR9); NF-κB and MAPK signaling pathways; Innate immune activation and adjuvant effect pathway |
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