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| Product name | CAS:2251722‑35‑5:Rimtoregtide |
| Description | Rimtoregtide is a structurally optimized triple receptor agonist metabolic peptide. It can simultaneously activate three receptors of GLP‑1, GIP and glucagon, exerting synergistic metabolic regulatory effects: GLP‑1 receptor pathway mediates glucose‑dependent hypoglycemia, food intake inhibition and gastric emptying delay; GIP receptor pathway improves insulin sensitivity and enhances weight loss effect; glucagon receptor pathway promotes lipolysis, increases energy expenditure and improves liver lipid accumulation. With significantly prolonged in vivo half‑life after modification, it is suitable for low‑frequency administration. Applied in mechanism research of metabolic diseases such as obesity, type 2 diabetes, non‑alcoholic steatohepatitis and peptide drug development. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Theoretical molecular weight (Da) | ~4800 (subject to actual synthetic batch) |
| Structure type | Site‑modified long‑chain peptide with balanced triple receptor agonistic activity |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Modification Type | Target |
| Rimtoregtide | Rimtoregtide; HM15211 | Triple receptor synergistic agonism, Hypoglycemic weight loss, Fatty liver improvement, Metabolic disease, Long-acting peptide, Triple-target agonist | Glucagon-like peptide backbone with site modifications balancing three receptor affinity and activity | Large modified peptide, subject to actual batch MS | - | ~4800 (theoretical) | Amino acid site substitution + side chain modification | GLP-1R/GCGR/GIPR |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-RIM001 | white powder | Store at -20℃, sealed, dry & protected from light, aliquoted; avoid repeated freeze-thaw cycles | Stable for 2 weeks at 2-8℃ sealed & dry; ice pack shipping recommended | Stable for 7 days at 4℃; prone to aggregation in neutral high-concentration solution**Moderate water solubility, soluble in dilute acetic acid or weakly acidic buffer, limited solubility in neutral solution**. Anti-enzymatic ability significantly better than native peptide after modification | Stable for 2 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-RIM001 | GLP-1/GIP/glucagon triple receptor agonist peptide that synergistically regulates glucose and lipid metabolism, lowers blood glucose, reduces weight and improves fatty liver | Rimtoregtide exerts synergistic metabolic effects by simultaneously activating three G protein-coupled receptors: activates GLP-1 receptors to promote insulin secretion in a glucose-dependent manner, inhibit glucagon release, delay gastric emptying, reduce food intake, and steadily control blood glucose; activates GIP receptors to improve insulin sensitivity and synergistically enhance weight loss effect; activates glucagon receptors to promote fat mobilization and decomposition, increase energy expenditure, and reduce hepatic triglyceride deposition. The three pathways work synergistically to achieve significant weight loss and liver metabolic improvement while controlling blood glucose, with better effect than single-target GLP-1 agonists. | Obesity and weight loss research, Type 2 diabetes, Non-alcoholic steatohepatitis, Glucose-lipid metabolism regulation, Triple receptor agonists, Metabolic peptide drugs | GLP-1 Receptor / GIP Receptor / Glucagon Receptor; cAMP/PKA signaling pathway; Glucose-lipid metabolism and energy expenditure regulatory pathway |
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