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| Product name | CAS:252845‑37‑7:Veldoreotide |
| Description | Veldoreotide is a structurally optimized long‑acting somatostatin analog. It binds multiple somatostatin receptor subtypes such as SSTR1, SSTR2, SSTR4 and SSTR5 with high affinity, and potently inhibits the secretion of pituitary growth hormone, thyroid‑stimulating hormone, as well as gastrointestinal hormones such as glucagon, insulin and gastrin by activating downstream receptor signaling pathways. After modification, its ability to resist peptidase degradation is enhanced, with much longer in vivo half‑life than native somatostatin and more durable effect. Applied in mechanism research of acromegaly, neuroendocrine tumors, gastroenteropancreatic endocrine diseases and peptide drug development. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Theoretical molecular weight (Da) | ~1100 (subject to actual synthetic batch) |
| Structure type | Cyclic octapeptide analog, one pair of disulfide bonds, optimized by site modification |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Structural Feature | Target |
| Veldoreotide | Veldoreotide; Somatostatin analog | Multi-subtype somatostatin receptor agonism, Hormone secretion inhibition, Acromegaly, Neuroendocrine tumor, Long-acting stable, Endocrine peptide | Somatostatin homologous octapeptide backbone with disulfide bond cyclization, site modifications optimizing receptor profile and stability | Large cyclic peptide, subject to actual batch MS | - | ~1100 (theoretical) | One pair of intramolecular disulfide bonds | Somatostatin receptors (multi-subtype) |
Physicochemical Solubility & Storage Parameters
| Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| white powder | Store at -20℃, sealed, dry & protected from light, strictly avoid reducing agents, aliquoted; avoid repeated freeze-thaw cycles | Stable for 1 month at 2-8℃ sealed & dry; ice pack shipping recommended | Stable for 14 days at 4℃; disulfide bonds break and inactivate under strong reducing agents**Moderate water solubility, soluble in dilute acetic acid or weakly acidic buffer**. Cyclic structure significantly enhances enzymatic resistance | Stable for 3 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-VEL001 | Multi-subtype somatostatin receptor agonist long-acting peptide that potently inhibits the secretion of various endocrine hormones | Veldoreotide binds somatostatin receptors on target cell surface, activates Gi protein-mediated signaling pathway, inhibits adenylate cyclase activity and reduces intracellular cAMP level, thereby broadly inhibits the synthesis and secretion of various endocrine hormones: has the strongest inhibitory effect on pituitary growth hormone and prolactin, and also inhibits the secretion of gastroenteropancreatic hormones such as glucagon, insulin, gastrin and vasoactive intestinal peptide. Its cyclic structure resists peptidase degradation, with much longer in vivo half-life than native linear somatostatin, longer duration of action, and wider coverage of receptor subtypes, suitable for the study of various endocrine diseases and tumors. | Acromegaly research, Neuroendocrine tumors, Gastroenteropancreatic endocrine diseases, Hormone secretion regulation, Somatostatin receptors, Peptide drug development | Somatostatin Receptors (SSTR1/2/4/5); Gi/cAMP signaling pathway; Endocrine hormone secretion inhibitory pathway |
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