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| Product name | CAS:2460862-12-6:Utreglutide |
| Description | Utreglutide is a long-acting GLP-1 receptor agonist. Aib substitution and side-chain C18 fatty acid modification improve metabolic stability, and albumin binding prolongs half-life. It is applied in mechanism research of type 2 diabetes, obesity and glucolipid metabolism. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Molecular formula | C₁₉₁H₂₉₈N₄₆O₅₈ |
| Molecular weight (Da) | 4166.67 |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Full Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Average MW (Da) | N-terminal Modification | C-terminal Modification | Sequence Length (aa) |
| Utreglutide | Utreglutide; Long-acting GLP-1 agonist; CAS 2460862-12-6 | GLP-1 receptor agonist,Long-acting metabolic peptide,Type 2 diabetes research,Obesity research,Albumin-binding long-acting,Glucolipid homeostasis regulation | Histidine-α-aminoisobutyric acid-glutamic acid-glycine-threonine-phenylalanine-threonine-serine-aspartic acid-valine-serine-serine-tyrosine-leucine-glutamic acid-glycine-glutamine-alanine-alanine-lysine(side-chain conjugated AEEA-Aib-γ-Glu-C18 fatty diacid)-glutamic acid-phenylalanine-isoleucine-alanine-tryptophan-leucine-valine-arginine-glycine-arginine-glycine-leucine | C₁₉₁H₂₉₈N₄₆O₅₈ | 4164.21 | 4166.67 | Free amine, with Aib unnatural amino acid substitution | Free carboxyl | 32 (core peptide backbone with side-chain long-acting modification) |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-UTR001 | white powder | Solid powder: store at -20℃, protected from light, sealed and dry, aliquoted; avoid repeated freeze-thaw cycles | Solid powder stable for 2 years at 2-8℃ sealed and dry; stock solutions recommended to be prepared in DMSO and stored at -80℃ in aliquots | Stable for 72 h at 4℃; stable for 6 months at -80℃ in aliquots; stable for 1 month at -20℃ in aliquots. **Poor water solubility, DMSO required for solubilization**. Prone to aggregation and fibrillation upon prolonged storage; avoid repeated freeze-thaw and vigorous shaking | Stable for 3 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-UTR001 | Long-acting GLP-1 receptor agonist with fatty acid modification for prolonged half-life, improves glucolipid metabolism and energy expenditure, applied in diabetes and obesity research | Utreglutide is a long-acting glucagon-like peptide-1 receptor (GLP-1R) agonist. Its core backbone is engineered from the GLP-1 sequence, with Aib substitution at position 2 to significantly enhance DPP-IV resistance, and a C18 fatty diacid conjugated to the lysine at position 20 via an AEEA-Aib-γ-Glu linker, prolonging in vivo half-life via serum albumin binding and supporting once-weekly administration. It specifically activates GLP-1 receptors to mediate glucose-dependent insulin secretion, suppress glucagon release, delay gastric emptying and inhibit appetite. It also upregulates FGF21 and UCP-1 expression in adipose tissue to promote energy expenditure and lipolysis, improving glucolipid metabolism. Preclinical studies demonstrate potent glucose-lowering and weight loss effects, making it a core tool molecule for type 2 diabetes, obesity and metabolic syndrome mechanism research, as well as long-acting GLP-1 drug development. | Type 2 diabetes research,Obesity mechanism research,Glucolipid metabolism research,Long-acting peptide drug development,Energy metabolism regulation research,GLP-1 pathway research | Glucagon-Like Peptide-1 Receptor (GLP-1R); cAMP/PKA insulin secretion pathway; Appetite and gastric emptying regulatory pathway; Adipose tissue thermogenesis pathway |
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