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| Product name | Mazdutide TFA |
| Description | Mazdutide is a GLP-1/glucagon dual receptor co-agonist. Aib substitution and side-chain C18 fatty acid modification achieve long-acting metabolic stability. Applied in mechanism research of obesity, type 2 diabetes and NASH. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Theoretical free base molecular weight | ~4568 Da |
| Salt form | TFA salt (TFA count subject to actual batch) |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Full Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Average MW (Da) | N-terminal Modification | C-terminal Modification | Sequence Length (aa) |
| Mazdutide TFA | Mazdutide TFA; IBI362 TFA; GLP-1/GCGR dual agonist | GLP-1/glucagon dual receptor co-agonist,Long-acting metabolic peptide,Obesity research,NASH research,Albumin-binding long-acting,Glucolipid metabolism improvement | Histidine-α-aminoisobutyric acid-glutamine-glycine-threonine-phenylalanine-threonine-serine-aspartic acid-tyrosine-serine-lysine-tyrosine-leucine-aspartic acid-serine-arginine-arginine-alanine-glutamine-aspartic acid-phenylalanine-valine-glutamine-tryptophan-leucine-leucine-lysine(side-chain conjugated γ-Glu-AEEA linker-C18 fatty diacid)-threoninamide | Varies with TFA count; free base theoretical C₂₁₀H₃₂₀N₄₄O₆₅ | - | ~4568 Da (free base) | Free amine, with Aib unnatural amino acid | Amidation | 29 (core backbone with side-chain modification) |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-MAZ001 | white powder | Store at -20℃, strictly protected from light, sealed and dry, aliquoted; avoid repeated freeze-thaw cycles and aggregation | Solid powder stable for 2 years at 2-8℃ sealed and dry; stock solutions recommended to be prepared in DMSO | Stable for 72 h at 4℃; stable for 6 months at -80℃ in aliquots; stable for 1 month at -20℃ in aliquots. **Poor water solubility, DMSO required**. Prone to aggregation and fibrillation upon prolonged storage; avoid repeated freeze-thaw and vigorous shaking | Stable for 3 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-MAZ001 | GLP-1/glucagon dual receptor co-agonist with synergistic weight loss and metabolic improvement, applied in obesity and metabolic disease research | Mazdutide (development code IBI362) is a long-acting dual agonist of GLP-1 receptor (GLP-1R) and glucagon receptor (GCGR). Aib amino acid substitution enhances enzymatic stability, and a C18 fatty diacid conjugated to the lysine side chain via γ-Glu and AEEA linker prolongs in vivo half-life via albumin binding, supporting once-weekly administration. It simultaneously activates two metabolic pathways: GLP-1 pathway mediates glucose-dependent glucose lowering and appetite suppression; glucagon pathway promotes hepatic lipolysis and energy expenditure. The synergistic dual-target effect achieves superior weight loss and metabolic improvement to single-target agonists. Preclinical studies demonstrate significant body weight reduction, improved glucolipid metabolism and hepatic steatosis, making it a core tool for obesity, type 2 diabetes and NASH mechanism research, as well as dual-target peptide drug development. | Obesity mechanism research,Type 2 diabetes research,NASH research,Glucolipid metabolism research,Dual-target peptide drug development,Energy metabolism regulation research | GLP-1 Receptor (GLP-1R); Glucagon Receptor (GCGR); cAMP/PKA metabolic regulatory pathway; Hepatic lipolysis pathway |
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