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| Product Name | CAS: 34273-11-1 (free peptide) Saralasin TFA |
| Description | Saralasin is the first synthetic competitive angiotensin Ⅱ antagonist, an octapeptide structural analog. It competitively binds to AT1 receptors on vascular smooth muscle, blocks the vasoconstrictive and pressor effects of endogenous angiotensin Ⅱ, exerts hypotensive effects, and has weak partial agonist activity. It is a classic tool peptide for renin-angiotensin system function research, hypertension mechanism study and renovascular hypertension diagnosis, widely used in cardiovascular pharmacology, receptor functional identification and antihypertensive drug development experiments. |
| Peptide Purity (HPLC, %) | 95% / 98% / 99% |
| Free peptide molecular formula | C₄₂H₆₅N₁₃O₁₀ |
| Free peptide molecular weight (Da) | 912.05, higher for TFA salt form |
| Structure type | Modified octapeptide, N-terminal sarcosine modification, trifluoroacetate salt |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Saralasin TFA | Saralasin trifluoroacetate | Competitive AT1 receptor antagonist, hypotensive, renin-angiotensin system research | Angiotensin Ⅱ octapeptide analog with Asp1→sarcosine (Sar) and Phe8→Ala; retains receptor binding activity with very low intrinsic activity, competitive antagonist with weak partial agonist activity | Free base: C₄₂H₆₅N₁₃O₁₀; Salt form: C₄₂H₆₅N₁₃O₁₀·xC₂HF₃O₂ | 911.5 | 912.05 | Trifluoroacetate (TFA) | 8 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-SAR001 | white powder | Store at -20°C, sealed, dry and protected from light. Aliquot to avoid repeated freeze-thaw cycles. | Stable for 1 month at 2–8°C in sealed dry condition; ship on ice pack recommended. | Stable for 14 days at 4°C. Freely soluble in water, dilute acetic acid and physiological buffers. Aqueous solution is susceptible to proteolytic degradation; aliquot sterilely and freeze after reconstitution. | Stable for 3 years at -20°C, dry and protected from light. |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-SAR001 | First synthetic competitive AT1 antagonist, tool for renin-angiotensin system research | Saralasin is the first synthetic competitive angiotensin Ⅱ antagonist, an octapeptide structural analog. It competitively binds to AT1 receptors on vascular smooth muscle, blocks the vasoconstrictive and pressor effects of endogenous angiotensin Ⅱ, exerts hypotensive effects, and has weak partial agonist activity. It is a classic tool peptide for renin-angiotensin system function research, hypertension mechanism study and differential diagnosis of renovascular hypertension, widely used in cardiovascular pharmacology, receptor functional identification and antihypertensive drug development experiments. | Hypertension mechanism study, renin-angiotensin system research, cardiovascular pharmacology, receptor functional identification, antihypertensive drug development | Angiotensin Ⅱ type 1 receptor (AT1R); Vasoconstriction / blood pressure regulation pathway |
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