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| Product name | CAS:160212-35-1:Nelipepimut-S |
| Description | Also known as E75 peptide, it is a high-affinity HLA-A*0201 CTL epitope peptide derived from human epidermal growth factor receptor 2 (HER2/neu). It induces specific cellular immune responses to kill HER2-positive tumor cells, and is applied in tumor vaccine and immunotherapy research of breast cancer, ovarian cancer and other malignancies. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Molecular formula | C₅₀H₇₈N₁₀O₁₁ |
| Molecular weight (Da) | 995.21 |
Products Description
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Full Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Average MW (Da) | N-terminal Modification | C-terminal Modification | Sequence Length (aa) |
| Pasireotide pamoate | Pasireotide pamoate; SOM230 pamoate; Signifor; CAS 396091-79-5 | Broad-spectrum SSTR agonist,High SSTR5 activity,Cushing's disease research,Acromegaly study,Hormone secretion suppression,Long-acting sustained release | Cyclohexapeptide core: Hydroxyproline-phenylglycine-D-tryptophan-lysine-O-benzyltyrosine-phenylalanine (backbone peptide bond cyclization, hydroxyproline side chain conjugated with aminoethyl carbamate) | C₈₁H₈₂N₁₀O₁₅ (1:1 pamoate) | 1434.6 | 1435.58 | Backbone cyclized, no free amine | Backbone cyclized, no free carboxyl | 6 (cyclohexapeptide core with multiple unnatural amino acids and side-chain modifications) |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-PAS001 | white powder | Store at -20℃, strictly protected from light, sealed and dry, aliquoted; avoid high temperature and moisture | Solid powder stable for 2 years at 2-8℃ sealed and dry; stock solutions recommended to be prepared in DMSO | Stable for 72 h at 4℃ in dark; stable for 1 month at -20℃ in aliquots. **Poor water solubility, DMSO required for solubilization**. Pamoate salt has significantly lower water solubility than acetate. Hygroscopic, strictly sealed for moisture protection | Stable for 3 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-PAS001 | Broad-spectrum multi-subtype somatostatin receptor agonist with high SSTR5 activity, potently inhibits ACTH and growth hormone secretion | Pasireotide is a six-membered cyclic peptide analog optimized based on the native somatostatin backbone. By introducing multiple unnatural amino acids and side-chain modifications, it achieves high-affinity binding to four somatostatin subtypes SSTR1, SSTR2, SSTR3 and SSTR5, especially over 40-fold higher SSTR5 activity than octreotide. It potently inhibits secretion of multiple hormones including adrenocorticotropic hormone (ACTH), growth hormone, insulin and glucagon, and simultaneously inhibits tumor cell proliferation and angiogenesis. It has a broader action spectrum and stronger potency, and remains effective on octreotide-resistant neuroendocrine tumors. It serves as a core tool molecule for mechanism research of Cushing's disease, acromegaly, neuroendocrine tumors and new-generation somatostatin drug development. The pamoate salt form is mostly used in long-acting sustained release formulation research. | Cushing's disease research,Acromegaly study,Neuroendocrine tumor research,Somatostatin pathway study,Hormone secretion regulation research,Long-acting sustained release development | Somatostatin Receptors SSTR1/2/3/5; cAMP/PKA signaling pathway; Hormone secretion and tumor proliferation regulatory pathway |
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