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| Product name | CAS:160212-35-1:Nelipepimut-S |
| Description | Also known as E75 peptide, it is a high-affinity HLA-A*0201 CTL epitope peptide derived from human epidermal growth factor receptor 2 (HER2/neu). It induces specific cellular immune responses to kill HER2-positive tumor cells, and is applied in tumor vaccine and immunotherapy research of breast cancer, ovarian cancer and other malignancies. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Molecular formula | C₅₀H₇₈N₁₀O₁₁ |
| Molecular weight (Da) | 995.21 |
Products Description
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Full Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Average MW (Da) | N-terminal Modification | C-terminal Modification | Sequence Length (aa) |
| Nelipepimut-S | Nelipepimut-S; E75 peptide; HER2 369-377 peptide; NeuVax; CAS 160212-35-1 | HER2 targeting,Tumor vaccine peptide,CTL epitope,HLA-A2 restricted,Breast cancer research,Cellular immunotherapy | Lysine-isoleucine-phenylalanine-glycine-serine-leucine-alanine-phenylalanine-leucine | C₅₀H₇₈N₁₀O₁₁ | 994.58 | 995.21 | Free amine, no modification | Free carboxyl, no modification | 9 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-NEL001 | white powder | Store at -20℃, sealed, dry & protected from light, aliquoted; avoid repeated freeze-thaw cycles | Solid powder stable for 1 year at 2-8℃ sealed and dry; prepare aqueous solutions freshly before use | Stable for 48 h at 4℃; stable for 2 weeks at -20℃ in aliquots. **Limited water solubility, small amount of DMSO or dilute acetic acid required for solubilization**. Unmodified short peptide easily degraded by peptidases with poor room-temperature stability | Stable for 2 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-NEL001 | HER2-derived HLA-A2 restricted CTL epitope peptide inducing specific cellular immunity to kill HER2-positive tumors | Nelipepimut-S (E75) is a classic high-affinity HLA-A*0201 CTL epitope peptide screened from residues 369-377 of human HER2/neu protein, and the core antigen of the world's first phase III breast cancer therapeutic vaccine. It can be processed by antigen-presenting cells and combined with HLA-A2 molecules to form peptide-MHC complexes, activate naive CD8+ T cells to differentiate into specific cytotoxic T lymphocytes, which precisely recognize and kill HER2-overexpressing tumor cells and reduce tumor recurrence risk. This epitope is immunogenic in various solid tumors such as breast cancer, ovarian cancer and gastric cancer, serving as a classic tool peptide for tumor immunotherapy research, therapeutic vaccine development and T cell activation mechanism analysis. | Tumor immunity research,Breast cancer research,Therapeutic vaccine development,Cellular immunotherapy research,HER2 pathway study,Solid tumor immunity research | HER2/neu protein epitope; HLA-A*0201 molecular presentation; CTL-mediated tumor cell killing pathway |
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