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| Product name | CAS 460738-38-9 Ecallantide |
| Sequence | Thr-Asp-Phe-Cys-Asn-Leu-Pro-Pro-Tyr-Thr-Gly-Pro-Cys-Val-Ala-Phe-Phe-Asp-Ile-Ala-Gly-Lys-Cys-Gln-Phe-Lys-Tyr-Asn-Gly-Glu-Gln-Asn-Arg-Phe-Tyr-Ser-Ala-Trp-Gly-Cys-Asp-Gly-Arg-Gly-Asn-Asn-Phe-Val-Tyr-Gly-Gly-Cys-Asp-Arg-Pro-Asn-Thr-Ser-Glu-Glu-Cys-Leu-Arg-Thr-Ala-Cys (Disulfide bridges: Cys4-Cys52, Cys13-Cys38, Cys23-Cys59) |
| Three letter sequence | H-Thr-Asp-Phe-Cys-Asn-Leu-Pro-Pro-Tyr-Thr-Gly-Pro-Cys-Val-Ala-Phe-Phe-Asp-Ile-Ala-Gly-Lys-Cys-Gln-Phe-Lys-Tyr-Asn-Gly-Glu-Gln-Asn-Arg-Phe-Tyr-Ser-Ala-Trp-Gly-Cys-Asp-Gly-Arg-Gly-Asn-Asn-Phe-Val-Tyr-Gly-Gly-Cys-Asp-Arg-Pro-Asn-Thr-Ser-Glu-Glu-Cys-Leu-Arg-Thr-Ala-Cys-OH |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Molecular formula | C₃₀₈H₄₇₈N₈₆O₉₄S₆ |
| Molecular weight (Da) | 7059.97 |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Amino Acid Full Name Sequence | Molecular Formula | Exact Molecular Weight (Da) | Average Molecular Weight (Da) | N-terminal Modification | C-terminal Modification | Sequence Length (aa) |
| Ecallantide | Ecallantide; DX-88; Kalbitor; CAS 460738-38-9; Plasma kallikrein inhibitor | Plasma kallikrein inhibitor,Bradykinin production inhibition,Hereditary angioedema therapy,Serine protease inhibitor,Inflammation regulation research | Thr-Asp-Phe-Cys-Asn-Leu-Pro-Pro-Tyr-Thr-Gly-Pro-Cys-Val-Ala-Phe-Phe-Asp-Ile-Ala-Gly-Lys-Cys-Gln-Phe-Lys-Tyr-Asn-Gly-Glu-Gln-Asn-Arg-Phe-Tyr-Ser-Ala-Trp-Gly-Cys-Asp-Gly-Arg-Gly-Asn-Asn-Phe-Val-Tyr-Gly-Gly-Cys-Asp-Arg-Pro-Asn-Thr-Ser-Glu-Glu-Cys-Leu-Arg-Thr-Ala-Cys (3 disulfide bridges for globular conformation) | C₃₀₈H₄₇₈N₈₆O₉₄S₆ | 7055.42 | 7059.97 | Free amine, unmodified | Free carboxyl, unmodified | 60 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-ECA001 | white powder | Store at -20℃, protected from light, sealed and dry, aliquoted; avoid repeated freeze-thaw cycles and reducing agents | Solid powder stable for 2 years sealed and dry at 2-8℃; prepare aqueous solutions freshly before use, aliquots stable for 1 month at -20℃ | Stable for 72 h at 4℃; disulfide bonds sensitive to reducing agents and high temperature, avoid prolonged room temperature exposure | Stable for 3 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Target / Receptor |
| PEP-ECA001 | Highly selective reversible plasma kallikrein inhibitor that blocks bradykinin production, applied in hereditary angioedema attack and inflammation mechanism research | Ecallantide (development code DX-88) is a potent, highly selective plasma kallikrein inhibitor engineered from the Kunitz-type serine protease inhibitor scaffold. Its compact globular structure precisely fits into the active pocket of plasma kallikrein, competitively inhibiting the cleavage of high-molecular-weight kininogen and reducing bradykinin generation at the source. Bradykinin is the core mediator of increased vascular permeability, tissue edema, pain and inflammatory responses, so Ecallantide effectively relieves acute edematous attacks in patients with hereditary angioedema (HAE). Compared with C1 esterase inhibitor replacement therapy, it has a more direct target, smaller molecular weight, stronger tissue penetration, and does not interfere with other coagulation cascade pathways. Approved by the FDA for acute HAE attacks, it serves as a core tool molecule for inflammatory pharmacology, kallikrein-kinin system research and peptide enzyme inhibitor drug development. | Inflammation pharmacology research,Hereditary angioedema research,Kallikrein-kinin system research,Peptide enzyme inhibitor development,Vascular permeability regulation research | Plasma kallikrein; Bradykinin production pathway |
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