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| Product name | CAS:1488411-60-4:Invopressin |
| Description | Invopressin is a highly selective arginine vasopressin V1a receptor antagonist. It competitively blocks the vasoconstrictive effect of endogenous vasopressin with no significant activity on V2 receptors. Applied in mechanism research of hypertension, heart failure, vasospasm, water-salt metabolism and vasopressin pathways. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Molecular formula | C₄₆H₆₅N₁₃O₁₂S₂ (free base) |
| Molecular weight (Da) | 1024.22 |
| Terminal modifications | N-terminal deamination, C-terminal amidation |
Products Description
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Full Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Average MW (Da) | N-terminal Modification | C-terminal Modification | Sequence Length (aa) |
| Invopressin | Invopressin; V1a selective antagonist; CAS 1488411-60-4 | High-selectivity V1a receptor antagonism,Vasodilation,Hypertension research,Heart failure study,Vasopressin pathway study,Antivasospastic | β-Mercaptopropionic acid-tyrosine-phenylalanine-glutamine-asparagine-cysteine-proline-arginine-glycinamide (cyclized via Mpa1-Cys6 disulfide bridge, N-terminal deaminated) | C₄₆H₆₅N₁₃O₁₂S₂ | 1023.44 | 1024.22 | N-terminal deaminated, no free amine | Amidation | 9 (with unnatural Mpa terminus) |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-INV001 | white powder | Store at -20℃, strictly protected from light, sealed and dry, aliquoted. **Strictly prohibited from strong reducing agents** | Solid powder stable for 6 months at 2-8℃ sealed and dry; prepare aqueous solutions freshly before use | Stable for 48 h at 4℃; stable for 2 weeks at -20℃ in aliquots. **Good water solubility, freely soluble in water and dilute acetic acid**. Disulfide bridge is sensitive to strong reducing agents and prone to cleavage. Aqueous solution easily degraded by peptidases with poor room-temperature stability | Stable for 3 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-INV001 | Highly selective V1a vasopressin receptor antagonist that competitively blocks vasoconstrictive effects, applied in cardiovascular and vasopressin pathway research | Invopressin is a selective peptidergic antagonist of arginine vasopressin V1a receptor. N-terminal deamination and amino acid substitution optimize receptor binding properties. It binds with high affinity to V1a receptors on vascular smooth muscle, competitively blocks endogenous vasopressin binding, inhibits vasoconstriction and reduces peripheral vascular resistance, with no significant effect on V2 receptor-mediated antidiuretic effects. Its subtype selectivity is significantly superior to non-peptide antagonists. This molecule can be used in pathological mechanism research of hypertension, heart failure, cerebral vasospasm, hepatorenal syndrome and other diseases, and serves as a classic tool peptide for vasopressin receptor subtype functional identification and water-salt metabolism regulatory pathway analysis. | Hypertension research,Heart failure study,Cerebral vasospasm research,Vasopressin pathway study,Water-salt metabolism study,Cardiovascular pharmacology research | Arginine Vasopressin V1a Receptor (V1aR); Vascular smooth muscle contraction pathway; Vascular resistance regulatory pathway |
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