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| Product Name | CAS:577782-52-6: CTCE-0214 |
| Description | CTCE-0214 is a functional analog peptide of stromal cell-derived factor-1α (SDF-1α) and a highly selective CXCR4 receptor agonist. Upon receptor binding, it activates downstream signaling pathways and significantly inhibits the release of pro-inflammatory cytokines such as TNF-α induced by LPS and zymosan, exerting potent anti-inflammatory effects. Its intramolecular lactam cyclization greatly enhances peptidase resistance and in vivo stability. It shows definite tissue protective effects in sepsis and systemic inflammatory response syndrome models, and is widely used in inflammatory immunomodulation, chemokine receptor function studies and anti-inflammatory drug development. |
| Peptide Purity (HPLC, %) | 95% / 98% / 99% |
| Free peptide molecular formula | C₁₇₀H₂₅₄N₄₄O₄₀ |
| Free peptide molecular weight (Da) | 3554.11, higher for salt form |
| Structure type | Cyclized 31-mer peptide, intramolecular lactam bond cyclization, C-terminal amidation, free peptide / acetate salt |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| CTCE-0214 | CTCE-0214; SDF-1α analog peptide | CXCR4 receptor agonist, anti-inflammatory, immunomodulation, sepsis research | Linear 31-mer peptide, intramolecular lactam cyclization between Lys20 and Glu24, C-terminal amidation, SDF-1α functional analog | C₁₇₀H₂₅₄N₄₄O₄₀ | 3551.89 | 3554.11 | Free peptide / acetate | 31 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-CTC001 | white powder | Store at -20°C, sealed, dry and protected from light. Aliquot to avoid repeated freeze-thaw cycles. | Stable for 1 month at 2–8°C in sealed dry condition; ship on ice pack. | Stable for 7 days at 4°C. Solubility: ~90 mg/mL in DMSO. Low solubility in water; prepare aqueous solution by serial dilution. Lactam cyclization enhances peptidase resistance. | Stable for 3 years at -20°C, dry and protected from light. |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-CTC001 | SDF-1α analog peptide, selective CXCR4 agonist, potent anti-inflammatory and pro-inflammatory cytokine inhibition | CTCE-0214 is a peptide analog of stromal cell-derived factor-1α (SDF-1α) and a highly selective CXCR4 receptor agonist. Upon receptor binding, it activates downstream signaling pathways and significantly inhibits LPS- and zymosan-induced release of pro-inflammatory cytokines such as TNF-α, exerting potent anti-inflammatory effects. Its intramolecular lactam cyclization improves metabolic stability and receptor affinity. It shows definite protective effects in sepsis and systemic inflammatory response syndrome models, and is widely used in inflammatory immunomodulation and chemokine receptor function research. | Sepsis / septic shock research, systemic inflammatory response syndrome, chemokine receptor function, immunomodulation study, anti-inflammatory drug development | C-X-C chemokine receptor 4 (CXCR4); SDF-1α/CXCR4 signaling pathway |
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