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| Product name CAS:285571‑64‑4 | Barusiban |
| Description | Barusiban is a new‑generation highly selective peptidergic oxytocin receptor antagonist. It has high affinity for OXTR with negligible activity on V1a receptors, competitively blocks the uterotonic effect of endogenous oxytocin with no obvious vascular side effects. Applied in preterm labor mechanism, tocolytic drug and oxytocin receptor function research. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Theoretical molecular formula | C₄₈H₇₄N₁₂O₁₃S₂ |
| Theoretical molecular weight (Da) | ~1075.31 (subject to actual synthetic batch) |
| Terminal modifications | N‑terminal deamination, C‑terminal amidation |
Products Description
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Full Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Average MW (Da) | N-terminal Modification | C-terminal Modification | Sequence Length (aa) |
| Barusiban | Barusiban; FE 200440; Highly selective oxytocin antagonist; CAS 285571-64-4 | High OTR selectivity,Tocolysis,Antipreterm labor,High uterine selectivity,No vascular side effects,Reproductive pharmacology | β-Mercaptopropionic acid-D-ethyltyrosine-isoleucine-threonine-asparagine-cysteine-proline-ornithine-glycinamide (disulfide cyclized) | C₄₈H₇₄N₁₂O₁₃S₂ (theoretical) | 1074.49 | 1075.31 | N-terminal deaminated, no free amine | Amidation | 9 (including unnatural termini and modified amino acids) |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-BAR001 | white powder | Store at -20℃, strictly protected from light, sealed and dry, aliquoted. **Strictly prohibited from strong reducing agents** | Solid powder stable for 2 years at 2-8℃ sealed and dry; prepare aqueous solutions freshly before use | Stable for 72 h at 4℃; stable for 1 month at -20℃ in aliquots. **Good water solubility, freely soluble in water and dilute acetic acid**. Disulfide bridge is highly sensitive to strong reducing agents and prone to cleavage. D-amino acids significantly enhance enzymatic resistance, stability superior to native peptides | Stable for 3 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-BAR001 | Highly selective oxytocin receptor antagonist that competitively inhibits uterine contraction with no obvious vascular side effects | Barusiban is a new-generation peptidergic oxytocin receptor antagonist optimized through multiple structural modifications. Introduction of D-amino acids, side-chain alkylation and terminal modifications significantly improves affinity and subtype selectivity for oxytocin receptors (OXTR), with negligible affinity for vasopressin V1a receptors and almost no vascular side effects. It competitively binds to OXTR on uterine smooth muscle cell surfaces, blocks endogenous oxytocin-mediated calcium signaling pathways, inhibits rhythmic contraction of uterine smooth muscle and prolongs gestation. Compared with first-generation antagonists, it has higher receptor selectivity, better metabolic stability, longer in vivo duration and stronger uterine targeting. This molecule serves as a core tool peptide for preterm labor pathogenesis research, tocolytic drug development, oxytocin receptor subtype functional identification and reproductive endocrine pharmacology research. | Preterm labor mechanism study,Tocolytic drug development,Reproductive endocrinology research,Oxytocin receptor function study,Obstetric pharmacology research,Uterine smooth muscle study | Oxytocin Receptor (OXTR); Uterine smooth muscle contraction signaling pathway; Intracellular calcium regulatory pathway |
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