CAS 2484708-86-1 Argireline Acetate

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CAS 2484708-86-1 Argireline Acetate
Details
CAS: 2484708-86-1
Sequence: Ac-Glu-Glu-Met-Gln-Arg-Arg-NH₂ (Acetyl hexapeptide-8, botulinum-like hexapeptide)
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Related documents
COA/MS/HPLC Report
Peptide Dissolution and Storage Guide
Category
Skin Care Active Peptide / Neurotransmitter Inhibitory Anti-wrinkle Hexapeptide
Category
Pharmaceutical Peptides
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Description

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Product name CAS:2484708‑86‑1 Argireline acetate
Description Argireline, also known as acetyl hexapeptide‑8, is a classic botulinum‑like active hexapeptide. It reduces acetylcholine release at neuromuscular junctions by inhibiting vesicle fusion involving SNAP‑25 protein, smoothes muscle contraction dynamic wrinkles. Applied in anti‑wrinkle skin care, neurotransmitter release mechanism and synaptic function research.
Peptide purity (HPLC, %) 95%/98%/99%
Molecular formula C₃₄H₆₀N₁₄O₁₂S (free peptide)
Molecular weight (Da) 889.00 (free peptide), slightly higher for acetate
Terminal modifications N‑terminal acetylation, C‑terminal amidation, acetate salt

 

Products Description

 

Product Standard English Name Product Abbreviation / Alias Function Tags (comma-separated) Full Amino Acid Sequence Molecular Formula Exact Mass (Da) Average MW (Da) N-terminal Modification C-terminal Modification Sequence Length (aa)
Argireline acetate Argireline acetate; Acetyl hexapeptide-8; Botulinum-like hexapeptide; CAS 2484708-86-1 Anti-wrinkle skin care,Neurotransmitter inhibition,SNAP-25 antagonism,Dynamic wrinkle improvement,Mild & non-toxic,Synaptic function study Acetyl-glutamic acid-glutamic acid-methionine-glutamine-arginine-argininamide C₃₄H₆₀N₁₄O₁₂S (free peptide) 888.43 889 Acetylation, no free amine Amidation 6

 

Physicochemical Solubility & Storage Parameters

 

Product Code Appearance Long-term Storage Conditions Short-term Storage Conditions Liquid Stability Solid Powder Stability
PEP-ARG001 white powder Store at -20℃, sealed, dry & protected from light, stored under nitrogen in aliquots; avoid strong oxidizing agents Solid powder stable for 2 years at 2-8℃ sealed and dry; aqueous solutions can be refrigerated short-term Stable for 72 h at 4℃; stable for 1 month at -20℃ in aliquots. **Excellent water solubility, freely soluble in water and skin care matrices**. Methionine residue prone to oxidative inactivation. Terminal modifications enhance enzymatic resistance Stable for 3 years at -20℃ under dry, dark & nitrogen atmosphere

 

Functional Description

 

Product Code Frontend Short Summary (for search list display) Detailed Biological Function Description Applicable Research Areas (comma-separated) Targets / Pathways
PEP-ARG001 Botulinum-like hexapeptide that competitively inhibits vesicle fusion to reduce acetylcholine release and smoothen dynamic wrinkles Argireline is a synthetic hexapeptide designed by mimicking the N-terminal sequence of SNAP-25 protein. It competitively binds to corresponding sites in the SNARE complex and inhibits the fusion process of synaptic vesicles with cell membranes, thereby reducing acetylcholine release at neuromuscular junctions, lowering muscle contraction amplitude and smoothening dynamic wrinkles formed by repeated facial muscle contraction. Its action is mild and reversible, does not cleave synaptic proteins, and has no muscle paralysis risk or toxicity of botulinum toxin with high safety. It is one of the most widely used anti-wrinkle active peptides in the skin care field, and can also be used in basic research such as neurotransmitter release mechanism, synaptic vesicle fusion and neuromuscular transmission. Skin care active peptide development,Anti-wrinkle efficacy evaluation,Neurotransmitter release study,Synaptic function research,Neuromuscular transmission study,Skin pharmacology research SNAP-25 protein; SNARE vesicle fusion complex; Acetylcholine release regulatory pathway

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