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| Product Name | CAS:914454-00-5: Enfuvirtide acetate |
| Description | Enfuvirtide (also known as T-20) is the first approved peptide drug of the HIV fusion inhibitor class. It is a 36-amino-acid peptide derived from the C-terminal heptad repeat (HR2) of HIV-1 envelope glycoprotein gp41. It competitively binds to the N-terminal heptad repeat (HR1) of gp41 and prevents the formation of the active six-helix bundle fusion structure, thereby inhibiting the fusion of the HIV viral envelope with the host cell membrane and blocking viral entry. With potent inhibitory activity against HIV-1, it is a core tool peptide for AIDS therapy and drug-resistant strain research, and is widely used in viral fusion mechanism studies and antiviral peptide drug development. |
| Peptide Purity (HPLC, %) | 95% / 98% / 99% |
| Free peptide molecular formula | C₂₀₄H₃₀₁N₅₁O₆₄ |
| Free peptide molecular weight (Da) | 4492.0, higher for acetate form |
| Structure type | Linear 36-mer peptide, N-terminal acetylation and C-terminal amidation, acetate salt |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Enfuvirtide acetate | T-20; Enfuvirtide acetate | HIV fusion inhibitor, antiviral, blocks viral entry, anti-HIV-1 | Linear 36-mer peptide derived from the HR2 domain of HIV envelope glycoprotein gp41, with N-terminal acetylation and C-terminal amidation. Competitively binds to the HR1 region to inhibit six-helix bundle fusion structure formation. | Free base: C₂₀₄H₃₀₁N₅₁O₆₄; Salt form: C₂₀₄H₃₀₁N₅₁O₆₄·xC₂H₄O₂ | 4491.18 (free base) | 4492.0 (free base) | Acetate | 36 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-ENF001 | white powder | Store at -20°C, sealed, dry and protected from light. Aliquot to avoid repeated freeze-thaw cycles. | Stable for 1 month at 2–8°C in sealed dry condition; ship on ice pack recommended. | Stable for 14 days at 4°C. Aqueous solubility: ~100 mg/mL (sonication required); freely soluble in dilute acetic acid and PBS buffer. Aqueous solution is susceptible to proteolytic degradation; aliquot sterilely and freeze after reconstitution. | Stable for 3 years at -20°C, dry and protected from light. |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-ENF001 | First approved HIV fusion inhibitory peptide, targets gp41 to block viral membrane fusion | Enfuvirtide (T-20) is the world's first approved peptide drug of the HIV fusion inhibitor class, derived from the C-terminal heptad repeat (HR2) of HIV-1 envelope glycoprotein gp41. It competitively binds to the N-terminal heptad repeat (HR1) of gp41 and prevents the formation of the six-helix bundle active conformation required for viral membrane fusion, thereby inhibiting fusion of the HIV envelope with the host cell membrane and blocking viral entry into host cells. It has potent inhibitory activity against both wild-type and multiple drug-resistant HIV-1 strains, and serves as a classic tool peptide for AIDS therapy, drug-resistant strain mechanism research and antiviral peptide drug development. | HIV/AIDS research, viral membrane fusion mechanism, antiviral drug development, drug-resistant strain research | HIV envelope glycoprotein gp41 HR1 domain; Virus-host cell membrane fusion process |
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