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| Product Name | Apraglutide TFA |
| Description | Apraglutide is a long-acting, highly selective GLP-2 receptor agonist. It specifically activates GLP-2 receptors on intestinal epithelial cells, promotes intestinal mucosal epithelial cell proliferation, inhibits apoptosis, enhances intestinal barrier function, and increases intestinal nutrient absorption area. Optimized by sequence modification, it has significantly improved DPP-4 resistance and a much longer in vivo half-life than native GLP-2. It significantly improves intestinal structure and function in models of short bowel syndrome, intestinal mucosal injury and inflammatory bowel disease, serving as a core tool peptide for intestinal metabolic disease mechanism research and peptide drug development. |
| Peptide Purity (HPLC, %) | 95% / 98% / 99% |
| Free peptide molecular formula | C₁₆₈H₂₆₃N₄₇O₅₅ |
| Free peptide molecular weight (Da) | 3782.2, higher for TFA salt form |
| Structure type | Linear modified 33-mer peptide, peptidase-resistant site optimization, trifluoroacetate salt |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Apraglutide TFA | Long-acting GLP-2 analog | GLP-2 receptor agonist, intestinal mucosa repair, enhances intestinal barrier, short bowel syndrome research | Long-acting modified 33-mer peptide with site-specific amino acid substitution based on native GLP-2 backbone, significantly enhances DPP-4 resistance and prolongs in vivo half-life. | Free base: C₁₆₈H₂₆₃N₄₇O₅₅; Salt form: C₁₆₈H₂₆₃N₄₇O₅₅·xC₂HF₃O₂ | 3780.89 (free base) | 3782.2 (free base) | Trifluoroacetate (TFA) | 33 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-APR001 | white powder | Store at -20°C, sealed, dry and protected from light. Aliquot to avoid repeated freeze-thaw cycles. -80°C recommended for long-term storage. | Stable for 2 months at 2–8°C in sealed dry condition; stable for short-term shipping at ambient temperature. | Stable for 7 days at 4°C. Solubility: ~100 mg/mL in DMSO, ~5 mg/mL in water (dilute acetic acid assists dissolution). DPP-4 resistance is significantly superior to native GLP-2. | Stable for 2 years at -20°C, dry and protected from light. |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-APR001 | Long-acting GLP-2 receptor agonist, promotes intestinal mucosa repair and enhances barrier function | Apraglutide is a long-acting, highly selective glucagon-like peptide-2 (GLP-2) receptor agonist. It specifically activates GLP-2 receptors on intestinal epithelial cells, drives the downstream cAMP signaling pathway, promotes intestinal crypt cell proliferation, inhibits epithelial cell apoptosis, increases villus height and nutrient absorption area, and enhances intestinal tight junction barrier function. Modified by site-specific amino acid substitution, it has significantly improved DPP-4 resistance and a much longer in vivo half-life than native GLP-2. It significantly improves intestinal structure and function in models of short bowel syndrome, chemotherapy-induced mucositis and inflammatory bowel disease, and is a core tool peptide for intestinal metabolic disease mechanism research and peptide drug development. | Short bowel syndrome research, intestinal mucosal injury repair, inflammatory bowel disease study, intestinal barrier function research, metabolic peptide drug development | Glucagon-like peptide 2 receptor (GLP-2R); cAMP signaling pathway; Intestinal epithelial proliferation/apoptosis pathway |
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