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| Product name | Exendin derivative 1 |
| Description | This peptide is a structurally modified derivative of Exendin‑4, retaining the core domain for GLP‑1 receptor binding. It can specifically bind and activate GLP‑1 receptors on the surface of islet β cells, glucose‑dependently promote insulin secretion, inhibit glucagon release, delay gastric emptying, and lower blood glucose. After structural modification, its metabolic stability, receptor affinity or pharmacokinetic properties are optimized compared with native Exendin‑4. It is a customized tool peptide for GLP‑1 drug structure‑activity relationship research and metabolic disease mechanism research. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Theoretical molecular weight (Da) | ~4200 (subject to actual modified sequence) |
| Structure type | Exendin‑4 derived modified peptide |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Modification Type | Length (aa) |
| Exendin derivative 1 | Exendin derivative 1; Exendin-4 analog | GLP-1 receptor agonism, Hypoglycemic metabolic regulation, SAR research, Modified derivative peptide, Diabetes research, Metabolic peptide | Exendin-4 homologous backbone with site modifications for optimized activity and stability | Large modified peptide, subject to actual sequence | - | ~4200 (theoretical) | Amino acid site substitution / terminal modification | ~39 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-EXD001 | white powder | Store at -20℃, sealed, dry & protected from light, aliquoted; avoid repeated freeze-thaw cycles | Stable for 2 weeks at 2-8℃ sealed & dry; ice pack shipping recommended | Stable for 7 days at 4℃; stability better than native Exendin-4 after modification**Moderate water solubility, soluble in dilute acetic acid or weakly acidic buffer**. Solubility slightly varies with modification degree | Stable for 2 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-EXD001 | Structurally modified Exendin-4 derivative that retains GLP-1 receptor agonistic activity with optimized metabolic and receptor properties | This derivative performs amino acid substitution, terminal modification or side chain engineering on specific sites of Exendin-4, and on the basis of retaining the core activity of GLP-1 receptor agonism, specifically optimizes certain properties: such as improving receptor binding affinity, enhancing resistance to dipeptidyl peptidase degradation, prolonging in vivo half-life, and improving tissue distribution characteristics. It can glucose-dependently promote insulin secretion, inhibit excessive glucagon release, delay gastric emptying, reduce food intake, and exert metabolic regulatory effects of hypoglycemia and weight loss. It is mainly used for structure-activity relationship research and drug screening of GLP-1 peptides. | Type 2 diabetes research, Obesity metabolism research, GLP-1 structure-activity relationship, Peptide drug screening, Islet function research, Metabolic disease mechanism | Glucagon-Like Peptide-1 Receptor (GLP-1R); cAMP/PKA signaling pathway; Insulin secretion and glucose metabolism regulatory pathway |
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