Shanghai Sonyt Biotechnology Co., Ltd. is one of the leading manufacturers and suppliers of cas 258818-34-7 larazotide in China, also supports custom service. Welcome to wholesale bulk high quality cas 258818-34-7 larazotide from our factory. Contact us for more details.
| Product name | CAS:258818‑34‑7:Larazotide |
| Description | Larazotide is an octapeptide intestinal barrier regulator derived from cholera toxin B subunit. It specifically binds the zonulin receptor on intestinal epithelial cells, blocks zonulin‑mediated tight junction opening, reduces intestinal permeability, and repairs intestinal barrier function. It can reduce translocation of luminal toxins, bacteria and inflammatory factors, and improve symptoms related to intestinal barrier dysfunction. Applied in mechanism research and intestinal repair peptide drug development for celiac disease, irritable bowel syndrome, inflammatory bowel disease, autoimmune diseases and other fields. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Molecular formula | C₃₄H₅₈N₈O₁₀ |
| Molecular weight (Da) | 722.88 |
| Structure type | Linear octapeptide, tight junction regulator |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Full Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Terminal Modification | Length (aa) |
| Larazotide | Larazotide acetate; Tight junction regulatory peptide | Intestinal barrier repair, Reduced intestinal permeability, Zonulin blockade, Celiac disease research, IBS, Intestinal barrier regulator | Gly-Gly-Val-Leu-Val-Gln-Pro-Gln | C₃₄H₅₈N₈O₁₀ | 722.43 | 722.88 | Native free termini | 8 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-LRZ001 | white powder | Store at -20℃, sealed, dry & protected from light, aliquoted; avoid repeated freeze-thaw cycles | Stable for 2 weeks at 2-8℃ sealed & dry; ice pack shipping recommended | Stable for 48h at 4℃; easily degraded by peptidases at room temperature with rapid activity decay,**Excellent water solubility, freely soluble in water and physiological buffer**; native unmodified short peptide, easily degraded by aminopeptidases and endopeptidases | Stable for 2 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-LRZ001 | Competitive zonulin-blocking octapeptide regulator that repairs intestinal barrier, reduces permeability and improves celiac and IBS symptoms | Larazotide mimics the binding site of endogenous zonulin, competitively binds to zonulin receptors on the surface of intestinal epithelial cells, inhibits downstream actin rearrangement, and prevents dissociation and opening of tight junction proteins, thereby stabilizing the intestinal epithelial tight junction structure, reducing intestinal permeability, and decreasing paracellular leakage of luminal contents. It can effectively block the transepithelial translocation of food antigens, bacterial endotoxins and inflammatory factors, and alleviate local intestinal and systemic secondary inflammatory responses. After oral administration, the peptide acts locally in the intestine with very low systemic absorption, high safety and no obvious systemic side effects. | Celiac disease research, Irritable bowel syndrome, Intestinal barrier function, Inflammatory bowel disease, Autoimmune intestinal injury, Gastrointestinal repair peptides | Zonulin receptor; Tight junction protein regulatory pathway; Intestinal paracellular permeability regulatory pathway |
Hot Tags: cas 258818-34-7 larazotide, China cas 258818-34-7 larazotide manufacturers, suppliers, factory, 2381089-83-2, 910463-68-2, CAS 910463 68 2, Melanotan II, pharmaceutical peptides, Retatrutide
