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| Product name | NODAGA‑LM3 TFA |
| Description | NODAGA‑LM3 is a bifunctional modified peptide obtained by covalently conjugating macrocyclic chelator NODAGA (1,4,7‑triazacyclononane‑1,4‑diacetic acid‑7‑glutaric acid) with targeting peptide LM3 via stable covalent bond. The LM3 peptide segment specifically binds to target molecules highly expressed on tumor cell surface for tumor targeting; the NODAGA chelating group can efficiently complex radioactive metal nuclides such as ⁶⁸Ga, ⁶⁴Cu and ¹⁷⁷Lu for PET/SPECT molecular imaging or targeted radionuclide therapy. The trifluoroacetate salt is an HPLC purification intermediate, and salt exchange to suitable form is recommended before chelation reaction. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Theoretical molecular weight (Da) | ~2100 (subject to actual synthetic batch) |
| Structure type | Chelator‑modified targeted peptide, trifluoroacetate salt |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Structure Type |
| NODAGA-LM3 TFA | NODAGA-LM3 TFA salt | Tumor targeting, Radionuclide imaging, Chelator conjugation, PET/SPECT probe, Targeted radionuclide therapy, Modified peptide | Targeting peptide LM3 covalently conjugated with macrocyclic chelator NODAGA | Large modified peptide, subject to actual batch MS | - | ~2100 (theoretical) | Trifluoroacetate | Chelator-modified targeted peptide |
Physicochemical Solubility & Storage Parameters
| Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| white powder | Store at -20℃, sealed, dry & protected from light, strictly avoid free metal ions, aliquoted; avoid repeated freeze-thaw cycles | Stable for 1 month at 2-8℃ sealed & dry; prepare solution freshly before chelation experiment | Stable for 7 days at 4℃. **Good water solubility, freely soluble in weakly acidic buffer**. Avoid contact with metal ions to prevent premature saturation of chelation sites | Stable for 2 years at -20℃ under dry & metal-free conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-NOD001 | Bifunctional targeted chelating peptide that specifically recognizes tumor targets and can complex radionuclides for imaging and therapy | NODAGA-LM3 exerts effects via the synergy of two functional modules: the LM3 peptide segment acts as a targeting ligand, specifically binding to target molecules highly expressed on tumor cell surface for targeted enrichment in tumor tissue; the NODAGA macrocyclic chelator acts as a nuclide binding site, rapidly complexing various positron nuclides and therapeutic nuclides under mild conditions to form stable radioactive complexes. The conjugate retains the targeting specificity of the peptide and the nuclide binding ability of the chelator, and can be used to construct tumor PET/SPECT molecular imaging probes and develop targeted radionuclide therapeutic drugs. | Tumor molecular imaging, Targeted radionuclide therapy, Nuclear medicine probe development, Tumor targeting research, Chelation chemistry, Peptide modification technology | Tumor cell surface target molecule; NODAGA-metal nuclide chelation; Tumor targeted enrichment and radionuclide imaging pathway |
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