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| Description | C-telopeptide (CAS: 162929-64-8) is an 8-residue short peptide from the C-terminal cross-link region of type I collagen, sequence Glu-Lys-Ala-His-Asp-Gly-Gly-Arg, molecular formula C34H56N14O13, MW 868.89 Da. Type I collagen makes up ~90% of bone organic matrix; cross-linked C-telopeptides (CTX-I) released during osteoclast-mediated resorption enter blood and urine, and their levels correlate with resorption rate and bone mineral density. This peptide is the standard antigen for serum/urine biochemical markers of osteoporosis, Paget disease, and tumor bone metastasis (e.g., CTX ELISA), and is used to study collagen cross-linking, collagenase degradation, and monitoring of anti-resorptive therapy. |
| Structure type | Linear 8-mer (type I collagen C-terminal cross-link region, bone-resorption marker) |
| Solubility | Readily soluble in water, PBS buffer |
| Storage | Powder -20C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Type I collagen C-terminal cross-linked telopeptide (C-telopeptide, CTX-I / CrossLaps; the 8-aa gold-standard bone-resorption marker) | C-telopeptide; CTX-I; CTX; CrossLaps; β-CTX; H-Glu-Lys-Ala-His-Asp-Gly-Gly-Arg-OH; EKAHDGGR-OH; type I collagen α1-chain C-telopeptide; CAS 162929-64-8 | bone resorption marker, type I collagen degradation, osteoporosis, CrossLaps/β-CTX, osteoclast, bone turnover, cross-linked telopeptide, free acid, water-soluble | Linear 8-aa small peptide, sequence H-Glu-Lys-Ala-His-Asp-Gly-Gly-Arg-OH (EKAHDGGR-OH), derived from the C-telopeptide region of the type I collagen α1 chain; C-terminal free acid, no amidation; side-chain net charge ~+1 (1 Arg + 1 Lys + 1 His positive, 1 Asp + 1 Glu negative, plus free N-terminus +1 and free C-terminus -1), pI on the basic side (~8); few hydrophobic residues (only Ala, ~12%); no Phe/Cys/Met/Trp (no disulfide/oxidation/photo-oxidation); highly hydrophilic with excellent water solubility. KEY STRUCTURAL NOTE: the immunoreactive CTX epitope (CrossLaps) released during osteoclastic bone resorption is commonly isomerized at position 5 Asp to isoaspartate (β-Asp, peptide bond formed via the Asp side-chain β-carboxyl) and partly racemized; this synthetic standard is supplied as the linear α-Asp free acid (identical formula/molecular weight to the β-Asp isomer, since isomerization changes only the side-chain linkage, not atomic composition), used for calibration curves and antibody controls | C34H56N14O13 | 868.42 | 868.91 | Free acid (C-terminal -COOH); no counterion salt; powder | 8 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-CTX-01 | White to off-white powder | Store at -20°C, sealed, desiccated, protected from light (~2 years). Aliquot to avoid repeated freeze-thaw. No Met/Cys/Trp-low oxidation/photo-oxidation; the small peptide is stable, keep dry and cold. | 2–8°C for up to ~1 month; working aliquots at -20°C; stable for shipping at ambient. | Hydrophilic small peptide with excellent water solubility. As an immunoassay standard, dilute in buffer containing a protein carrier (e.g., 0.1% BSA) to prevent low-concentration adsorption losses; the lyophilate is hygroscopic-weigh quickly and reseal. | solid stable for ~2 years at -20°C, sealed and desiccated; keep the desiccator sealed and the weighing environment dry. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-CTX-01 | An 8-aa peptide from the C-telopeptide of type I collagen-the gold-standard serum/urine marker (β-CTX/CrossLaps) released during osteoclastic bone resorption, used in osteoporosis and bone-turnover research. | The C-terminal cross-linked telopeptide (C-telopeptide, CTX-I; clinically β-CTX/CrossLaps) is an 8-aa sequence (EKAHDGGR) from the C-telopeptide region of the type I collagen α1 chain. When osteoclasts acidify resorption lacunae and degrade type I collagen in bone matrix, this C-telopeptide fragment is released into the circulation and excreted in urine; serum/plasma and urinary CTX-I therefore directly reflect the rate of osteoclast-mediated bone resorption. It is one of the most widely used biochemical markers for assessing bone-resorption activity, diagnosing and monitoring osteoporosis, and evaluating the efficacy of anti-resorptive agents (e.g., bisphosphonates, denosumab). The naturally released CTX epitope is commonly isomerized at position 5 Asp to isoaspartate (β-Asp) and partly racemized to D-Asp-an age-dependent post-translational modification that accumulates with collagen aging-and commercial CrossLaps immunoassays target this isomerized epitope. This product is a synthetic linear free-acid 8-aa standard (α-Asp form; same formula and molecular weight as the β-Asp isomer) used for calibration curves, immunoassay antibody development, osteoclast functional assays and quantitation in bone-turnover/osteoporosis research. | Bone metabolism, osteoporosis, bone-resorption marker (β-CTX/CrossLaps), osteoclast biology, anti-resorptive drug evaluation, bone-turnover biochemical markers, metabolic bone disease | Type I collagen α1-chain C-telopeptide (osteoclastic cathepsin-K degradation site); serum/urine bone-resorption epitope (including the β-Asp-isomerized epitope) |
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