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| Description | Fibrinopeptide A, human (CAS: 25422-31-5) is the 16-residue short peptide released by thrombin from the N-terminus of the human fibrinogen Aalpha chain, sequence Ala-Asp-Ser-Gly-Glu-Gly-Asp-Phe-Leu-Ala-Glu-Gly-Gly-Gly-Val-Arg, molecular formula C63H97N19O26, MW 1536.56 Da. Release of FPA by thrombin is the first step of fibrin clot formation in the coagulation cascade, and plasma FPA levels directly reflect in vivo thrombin activity. FPA is an important marker for thrombotic disease research (deep vein thrombosis, DIC) and a standard parent peptide for thrombin-activity assays and MS quantification (SISCAPA/MRM). |
| Structure type | Linear 16-mer (human fibrinogen Aalpha-chain thrombin-released peptide) |
| Solubility | Readily soluble in water, PBS buffer |
| Storage | Powder -20C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Fibrinopeptide A, human (16-aa peptide released by thrombin from the N-terminus of the fibrinogen Aα chain) | FpA; Fibrinopeptide A; Aα1-16; H-Ala-Asp-Ser-Gly-Glu-Gly-Asp-Phe-Leu-Ala-Glu-Gly-Gly-Gly-Val-Arg-OH; ADSGEGDFLAEGGGVR-OH; CAS 25422-31-5 | coagulation biomarker, fibrinopeptide, thrombin substrate, thrombosis, DIC, hypercoagulability, acidic peptide, free acid, water-soluble | Linear 16-aa acidic short peptide, sequence H-Ala-Asp-Ser-Gly-Glu-Gly-Asp-Phe-Leu-Ala-Glu-Gly-Gly-Gly-Val-Arg-OH (ADSGEGDFLAEGGGVR-OH; residues Aα1-16 of fibrinogen); C-terminal free acid, no amidation; side-chain net charge ~-3 (1 Arg positive, 2 Asp + 2 Glu negative, plus free N-terminus +1 and free C-terminus -1); hydrophobic fraction ~31% (Phe, Leu, Val, Ala); no Cys/Met/Trp (no disulfide/oxidation/photo-oxidation); contains 4 Gly (a C-terminal Gly-Gly-Gly run) giving a flexible backbone; rich in acidic residues with low pI and good aqueous solubility; the first fibrinopeptide released by thrombin, faster than FpB | C63H97N19O26 | 1535.69 | 1536.58 | Free acid (C-terminal -COOH); no counterion salt; powder | 16 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-FPAH-01 | White to off-white powder | Store at -20°C, sealed, desiccated, protected from light (~2 years). Aliquot to avoid repeated freeze-thaw. No Met/Cys/Trp-low oxidation/photo-oxidation; the small peptide is stable, keep dry and cold. | 2–8°C for up to ~1 month; working aliquots at -20°C; stable for shipping at ambient. | Acidic short peptide with good water solubility (soluble to several mg/mL in aqueous buffers); Phe/Leu add slight hydrophobicity-use dilute acetic acid or mild sonication if needed. No Cys (no disulfide), no Met (no oxidation), no Trp (no photo-oxidation). The lyophilate is hygroscopic-weigh quickly and reseal. | solid stable for ~2 years at -20°C, sealed and desiccated; keep the desiccator sealed and the weighing environment dry. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-FPAH-01 | The 16-aa peptide released by thrombin from the N-terminus of the fibrinogen Aα chain-the earliest and classic circulating marker of in-vivo thrombin generation and coagulation activation, used in thrombosis, DIC and hypercoagulability research. | Human fibrinopeptide A (FpA) is the 16-aa peptide (Aα1-16) released when thrombin cleaves the N-terminus of the fibrinogen Aα chain at the Arg16-Gly17 bond. During conversion of fibrinogen to fibrin, FpA release precedes and is faster than FpB: FpA release exposes the Aα-chain N-terminal 'A' polymerization knob, which binds complementary 'a' holes on other fibrin monomers to trigger longitudinal polymerization-one of the initiating events of fibrin clot formation. Plasma/serum FpA is a highly sensitive, direct marker of in-vivo thrombin generation and coagulation activation: it is very low in normal circulation but rises markedly in thrombosis, deep-vein thrombosis, DIC, acute myocardial infarction, stroke, sepsis-associated hypercoagulability, and during extracorporeal circulation/hemodialysis, and is widely used to monitor coagulation activation and hypercoagulable states. FpA and its N-terminal fragments also serve as molecular indicators of serum quality/aging (e.g., the SeraDeg score). This synthetic free-acid standard is used for calibration curves, antibody development, thrombin activity assays and studies of fibrin polymerization. | Coagulation & hemostasis, thrombosis, DIC, hypercoagulability, fibrinolysis research, fibrin polymerization mechanism, thrombin substrate/activity assays, biomarker detection | Fibrinogen Aα-chain N-terminus (thrombin cleavage site Arg16-Gly17); marker of in-vivo thrombin generation; fibrin longitudinal polymerization (knob 'A' exposure) |
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