Shanghai Sonyt Biotechnology Co., Ltd. is one of the leading manufacturers and suppliers of fibronectin adhesion-promoting peptide (trp-gln-pro-pro-arg-ala-arg-ile) in China, also supports custom service. Welcome to wholesale bulk high quality fibronectin adhesion-promoting peptide (trp-gln-pro-pro-arg-ala-arg-ile) from our factory. Contact us for more details.
| Description | Fibronectin Adhesion-promoting Peptide (FAP, CAS: 125720-21-0) is an octapeptide derived from the heparin-binding region of fibronectin, sequence Trp-Gln-Pro-Pro-Arg-Ala-Arg-Ile (WQPPRARI), molecular formula C₄₇H₇₄N₁₆O₁₀, MW 1023.19 Da. Synergizing with integrin-binding sites, FAP promotes cell adhesion, spreading, and migration; it is used to study fibronectin-mediated cell-matrix interactions and tissue-engineering surface functionalization. |
| Structure type | Linear 8-mer (fibronectin heparin-binding region adhesion sequence) |
| Solubility | Readily soluble in water, PBS |
| Storage | Powder -20°C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Fibronectin Adhesion-promoting Peptide (Trp-Gln-Pro-Pro-Arg-Ala-Arg-Ile) | Fibronectin Adhesion-promoting Peptide; FAP; Heparin Binding Peptide; WQPPRARI; H-Trp-Gln-Pro-Pro-Arg-Ala-Arg-Ile-OH; a fragment of the fibronectin C-terminal heparin-binding domain; CAS 125720-21-0; free base (free acid) | cell adhesion, fibronectin, integrin, focal adhesion, heparin-binding peptide, extracellular matrix, biomaterials/tissue engineering, Trp photo-sensitive, free base | Linear cationic 8-aa peptide, sequence Trp-Gln-Pro-Pro-Arg-Ala-Arg-Ile (WQPPRARI); free N-terminal amine and free C-terminal carboxyl; side chains are net positive (two Arg, no Asp/Glu/Lys/His; ~+3 including the N-terminus); two Pro residues give a rigid turn, one aromatic Trp side chain; hydrophobic residues (Trp, Ile, two Pro, Ala) ~5/8; no Cys/Met (no disulfide, no Met oxidation), but one Trp makes it somewhat light/oxidation sensitive; it is a cell-adhesion-promoting sequence within the fibronectin C-terminal heparin-binding domain (Hep-II / III12-14), distinct from the RGD site in III10; supplied as the free base/free acid, CAS 125720-21-0 (suppliers Sigma F3667 and MCE both list C47H74N16O10, MW ~1023.19, with no fluorine-confirming it is the free base, not a TFA salt) | C47H74N16O10 | 1022.58 | 1023.21 | Free base / free acid (no TFA); the formula is that of the free peptide C47H74N16O10 (exact 1022.58 / avg 1023.21 Da, matching Sigma F3667/MCE MW 1023.19; no F3 in the formula confirms it is not a TFA salt); CAS 125720-21-0. Although an earlier batch may have been a TFA-salt version, this batch at CAS 125720-21-0 is the free-base form. | 8 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-FAP-01 | White to off-white powder (contains Trp; protect from light) | Store at -20°C, sealed, desiccated, protected from light (~2 years). Aliquot to avoid repeated freeze-thaw. One Trp residue makes it light/oxidation sensitive-store in amber glass or foil-wrapped, sealed. No Cys/Met (no disulfide/Met oxidation). | 2–8°C, protected from light, for up to ~1 month; working aliquots at -20°C, protected from light; ship at ambient, protected from light and moisture. | A cationic short peptide (two Arg plus the N-terminal amine, net positive charge) with hydrophobic residues (Pro2-Trp-Ile-Ala); moderate-to-good water solubility (aqueous/mild buffers to several mg/mL; if slow to dissolve, use water with sonication or a slightly acidic buffer). Because it contains Trp, keep solutions protected from light and prepare fresh for short-term use. No free Cys (no dimerization) and no Met (no Met oxidation); Trp is prone to photo-oxidation in open, illuminated solutions, so keep working solutions under inert gas and in the dark. | The solid is stable for ~2 years at -20°C, sealed, desiccated and protected from light; always keep the Trp-containing peptide dark and dry. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-FAP-01 | WQPPRARI, an 8-aa peptide from the fibronectin C-terminal heparin-binding domain, promotes cell adhesion, spreading and focal-adhesion formation via heparin/heparan-sulfate and integrin pathways; a widely used adhesion motif for biomaterial surface functionalization and tissue engineering. | This is an 8-aa cell-adhesion-promoting peptide from the C-terminal heparin-binding domain of fibronectin (Hep-II, repeats III12–14), sequence Trp-Gln-Pro-Pro-Arg-Ala-Arg-Ile (WQPPRARI), also called Heparin Binding Peptide. Unlike the central cell-binding site in III10 that acts through the classic RGD motif and integrin α5β1, WQPPRARI uses its double-arginine basic cluster to bind cell-surface heparan-sulfate proteoglycans (syndecans and other heparin receptors) and to cooperate with integrin signaling, thereby promoting cell adhesion, spreading, stress-fiber and focal-adhesion assembly, and enhancing cell attachment and migration on matrices. Because it is short, contains a Pro-Pro turn, is cationic and can be coupled via its N-terminus, it is widely immobilized on biomaterials/hydrogels/tissue-engineering scaffolds to confer cell-adhesion activity, and serves as a tool peptide for heparin-binding and cell–matrix interaction studies. Supplied as the free base/free acid (CAS 125720-21-0, formula C47H74N16O10 with no fluorine), distinct from the TFA-salt version; it contains Trp, so store protected from light, deoxygenated, and prepare aqueous solutions fresh. | Cell adhesion and migration, extracellular-matrix biology, integrin/heparan-sulfate signaling, biomaterials and surface functionalization, tissue engineering, wound healing, heparin-binding peptides | Cell-surface heparan-sulfate proteoglycans/syndecans (heparin binding); cooperative integrin adhesion signaling; focal-adhesion/stress-fiber assembly pathways |
Hot Tags: fibronectin adhesion-promoting peptide (trp-gln-pro-pro-arg-ala-arg-ile), China fibronectin adhesion-promoting peptide (trp-gln-pro-pro-arg-ala-arg-ile) manufacturers, suppliers, factory, 93674-95-4, CAS 239075 62 8, CAS 93674 95 4, cell adhesion peptides, Dentonin, GRGDSPC
