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| Description | Arg-Gly-Asp-Ser-Pro (RGDSP, CAS: 110697-44-4) is a pentapeptide derived from the fibronectin cell-binding region, sequence Arg-Gly-Asp-Ser-Pro, molecular formula C₂₀H₃₄N₈O₉, MW 530.53 Da. The RGD (Arg-Gly-Asp) motif is specifically recognized by cell-surface integrins (αvβ3, αvβ5, α5β1, etc.), mediating cell adhesion, spreading, and signaling. RGDSP is widely used to improve biocompatibility of titanium dental-implant model surfaces, enhance cell viability in PEG-based hydrogels, and for integrin-targeted modification of cell-culture substrates and biomaterials. |
| Structure type | Linear RGD pentapeptide |
| Solubility | Readily soluble in water, PBS |
| Storage | Powder -20°C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| RGDSP (Arg-Gly-Asp-Ser-Pro; fibronectin-derived RGD pentapeptide) | RGDSP; Arg-Gly-Asp-Ser-Pro; H-Arg-Gly-Asp-Ser-Pro-OH; fibronectin cell-binding-domain RGD pentapeptide; C-terminal Pro-extended RGD peptide; free acid (no TFA); CAS 110697-44-4 | cell adhesion peptide, RGD motif, integrin ligand, fibronectin, cell culture coating, biomaterial surface functionalization, tissue engineering, integrin receptor research, free acid | Linear pentapeptide, sequence Arg-Gly-Asp-Ser-Pro (RGDSP), H-Arg-Gly-Asp-Ser-Pro-OH; free N-terminal amine and free C-terminal carboxyl (free acid, -COOH); near-neutral net charge (zwitterionic: 1 Arg - 1 Asp, N-terminus +, C-terminus -, ~0 at neutral pH); no Cys/Met/Trp (no disulfide/oxidation/photo-oxidation issues); extends a Ser-Pro C-terminally beyond the canonical Arg-Gly-Asp (RGD) integrin-recognition core, matching the natural sequence near the RGD site of the fibronectin cell-binding domain (III10/FIII10 module); the C-terminal Pro constrains the backbone near the RGD core and favors integrin recognition; the Asp side-chain carboxyl together with Gly and the Arg side chain forms the core triad recognized by multiple RGD-dependent integrins; supplied as the free acid (no TFA/counterion) | C20H34N8O9 | 530.24 | 530.54 | Free acid (C-terminal -COOH; no TFA/counterion); CAS 110697-44-4 | 5 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-RGDSP-01 | White to off-white powder | Store at -20°C, sealed, desiccated, protected from light (~2 years). Aliquot to avoid repeated freeze-thaw. No Met/Cys/Trp-low oxidation and photo-oxidation risk; the small-molecule lyophilate is chemically stable. The free acid form is only weakly hygroscopic. | 2–8°C for up to ~1 month; working aliquots at -20°C; stable for shipping at ambient. | Small zwitterionic peptide with good water solubility (mg/mL grade in pure water/aqueous buffer, near-neutral and readily soluble). No Cys (no disulfide), no Met (no oxidation), no Trp (no photo-oxidation). The lyophilate is only weakly hygroscopic-routine sealing suffices. As a cell-culture coating peptide, dissolve in sterile water or buffer and coat plates/slides/biomaterial surfaces; as a soluble competitor, prepare working solutions directly in medium or buffer. Supplied as the free acid with no TFA counterion, suitable for cell culture and in-vivo work; an RGE mutant of matched length can be used as a control to demonstrate RGD specificity. | solid stable for ~2 years at -20°C, sealed and desiccated; routine desiccator storage is sufficient. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-RGDSP-01 | The fibronectin-derived RGD pentapeptide RGDSP, carrying the canonical RGD integrin-recognition core plus a C-terminal Pro; binds integrins alphaV beta3/alphaV beta5/alpha5 beta1/alphaIIb beta3 and is used for cell-culture coating, biomaterial/tissue-engineering cell attachment and integrin receptor research. | RGDSP is a linear pentapeptide that extends a Ser-Pro beyond the canonical Arg-Gly-Asp (RGD) integrin-recognition core, mimicking the RGD cell-adhesion site in the fibronectin cell-binding domain (FIII10 module). Its RGD triad (Arg side chain, Gly, Asp side-chain carboxyl) is recognized by multiple RGD-dependent integrins, including alphaV beta3, alphaV beta5, alpha5 beta1 and alphaIIb beta3 (platelet GPIIb/IIIa). When immobilized on culture surfaces or biomaterials, RGDSP promotes cell attachment, spreading and survival; as a soluble competitor it blocks RGD-dependent adhesion. Typical uses: (1) coating culture plates/slides to promote attachment of anchorage-dependent cells (fibroblasts, endothelial cells) on synthetic or low-adhesion surfaces; (2) functionalizing tissue-engineering scaffolds and biomaterials to improve cell seeding efficiency and tissue regeneration; (3) integrin receptor binding and signaling (FAK/paxillin focal-adhesion pathways); (4) comparison with RGE negative-control peptides to demonstrate RGD specificity. Supplied as the free acid with no counterion, chemically stable and water-soluble, ready for direct cell and materials work; note that linear RGD peptides have lower affinity than cyclized RGD analogues, so optimize coating density when immobilized. | Cell adhesion, integrin biology, RGD signaling, cell culture coating, biomaterial surface functionalization, tissue engineering/regenerative medicine, integrin receptor research | RGD-dependent integrins alphaV beta3, alphaV beta5, alpha5 beta1, alphaIIb beta3 (GPIIb/IIIa); cell-ECM adhesion, spreading and migration (FAK/focal-adhesion) pathways |
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